Title:
INDUCERS OF RECOMBINANT PROTEIN EXPRESSION
Document Type and Number:
WIPO Patent Application WO2004096833
Kind Code:
A3
Abstract:
The invention provides methods of increasing the production of polypeptides, optionally recombinant polypeptides, from mammalian cells using an aromatic carboxylic acid, an acetamide, and/or a hydroxamic acid compound, and cultures containing the same.
Inventors:
ALLEN MARTIN J (US)
REDDY PRANHITHA (US)
BOYCE JAMES P (US)
FITZNER JEFFREY N (US)
REDDY PRANHITHA (US)
BOYCE JAMES P (US)
FITZNER JEFFREY N (US)
Application Number:
PCT/US2004/012590
Publication Date:
December 29, 2004
Filing Date:
April 23, 2004
Export Citation:
Assignee:
IMMUNEX CORP (US)
ALLEN MARTIN J (US)
REDDY PRANHITHA (US)
BOYCE JAMES P (US)
FITZNER JEFFREY N (US)
ALLEN MARTIN J (US)
REDDY PRANHITHA (US)
BOYCE JAMES P (US)
FITZNER JEFFREY N (US)
International Classes:
C07K16/00; C07K16/28; C12N5/00; (IPC1-7): C07K1/06; C12N5/16; C12N5/06; C12P21/20
Foreign References:
| US5378612A | 1995-01-03 | |||
| EP0239292A1 | 1987-09-30 | |||
| US6740505B1 | 2004-05-25 |
Other References:
GORMAN C M ET AL: "EXPRESSION OF RECOMBINANT PLASMIDS IN MAMMALIAN CELLS IS ENHANCED BY SODIUM BUTYRATE", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 11, no. 21, 1983, pages 7631 - 7648, XP002054816, ISSN: 0305-1048
PALERMO D P ET AL: "Production of analytical quantities of recombinant proteins in Chinese hamster overy cells using sodium butyrate to elevate gene expression", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 19, no. 1, June 1991 (1991-06-01), pages 35 - 48, XP002135791, ISSN: 0168-1656
SATOH K ET AL: "EFFECT OF DRUGS ON GENE EXPRESSION IN MAMMALIAN CELLS; A HIGHLY EFFICIENT PROCEDURE TO TEST LARGE NUMBERS OF SAMPLES", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 21, no. 18, 1993, pages 4429 - 4430, XP002056202, ISSN: 0305-1048
PALERMO D P ET AL: "Production of analytical quantities of recombinant proteins in Chinese hamster overy cells using sodium butyrate to elevate gene expression", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 19, no. 1, June 1991 (1991-06-01), pages 35 - 48, XP002135791, ISSN: 0168-1656
SATOH K ET AL: "EFFECT OF DRUGS ON GENE EXPRESSION IN MAMMALIAN CELLS; A HIGHLY EFFICIENT PROCEDURE TO TEST LARGE NUMBERS OF SAMPLES", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 21, no. 18, 1993, pages 4429 - 4430, XP002056202, ISSN: 0305-1048
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