Title:
INDUCING TCL1A EXPRESSION TO INCREASE PROLIFERATION AND PROLONG STEMNESS OF HEMATOPOIETIC STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2024/039600
Kind Code:
A3
Abstract:
Compositions and methods are provided for increasing proliferation of hematopoietic stem cells (HSC), and increasing HSC capacity for self-renewal. It is shown herein that overexpression of the protein TCL1A in HSC allows the cells to expand in absolute number to a greater number than unmodified cells, and to maintain stem cell surface markers in culture in media supplemented with cytokines.
More Like This:
| WO/2001/057068 | MUCIN-1 DERIVED ANTIGENS AND THEIR USE IN IMMUNOTHERAPY |
| WO/1996/001844 | PROTEINS ASSOCIATED WITH TUMOR NECROSIS FACTOR RECEPTOR |
| WO/1997/011176 | CYCLIN/CDK ASSOCIATED PROTEINS, AND USES RELATED THERETO |
Inventors:
JAISWAL SIDDHARTHA (US)
GOPAKUMAR JAYAKRISHNAN (US)
GOPAKUMAR JAYAKRISHNAN (US)
Application Number:
PCT/US2023/030141
Publication Date:
March 21, 2024
Filing Date:
August 14, 2023
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR (US)
International Classes:
C07K14/47; C12N5/0789; A61K35/545; C12N15/87
Other References:
WEINSTOCK JOSHUA S., GOPAKUMAR JAYAKRISHNAN, BURUGULA BALA BHARATHI, UDDIN MD MESBAH, JAHN NIKOLAUS, BELK JULIA A., DANIEL BENCE, : "Clonal hematopoiesis is driven by aberrant activation of TCL1A", BIORXIV, 13 December 2021 (2021-12-13), XP093025773, Retrieved from the Internet [retrieved on 20230221], DOI: 10.1101/2021.12.10.471810
CAROL S. LEUNG: "Analysis of ROR1 Protein Expression in Mice with Reconstituted Human Immune System Components", JOURNAL OF IMMUNOLOGY RESEARCH, HINDAWI PUBLISHING CORPORATION, US, vol. 2018, 1 January 2018 (2018-01-01), US , pages 1 - 10, XP093152540, ISSN: 2314-8861, DOI: 10.1155/2018/2480931
KATRIN S REINERS: "Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells", HAEMATOLOGICA, FONDAZIONE FERRATA STORTI, IT, vol. 102, no. 3, 1 March 2017 (2017-03-01), IT , pages e100 - e103, XP093152548, ISSN: 0390-6078, DOI: 10.3324/haematol.2016.153197
CAROL S. LEUNG: "Analysis of ROR1 Protein Expression in Mice with Reconstituted Human Immune System Components", JOURNAL OF IMMUNOLOGY RESEARCH, HINDAWI PUBLISHING CORPORATION, US, vol. 2018, 1 January 2018 (2018-01-01), US , pages 1 - 10, XP093152540, ISSN: 2314-8861, DOI: 10.1155/2018/2480931
KATRIN S REINERS: "Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells", HAEMATOLOGICA, FONDAZIONE FERRATA STORTI, IT, vol. 102, no. 3, 1 March 2017 (2017-03-01), IT , pages e100 - e103, XP093152548, ISSN: 0390-6078, DOI: 10.3324/haematol.2016.153197
Attorney, Agent or Firm:
SHERWOOD, Pamela J. (US)
Download PDF:
Previous Patent: PHENETHYLAMINES AND CATHINONES PRECURSORS
Next Patent: ELECTROMAGNETIC MOVEMENT BOARD
Next Patent: ELECTROMAGNETIC MOVEMENT BOARD