Title:
INERT CARRIER INDIRECT AGGLUTINATION TEST DETECTION SYSTEM AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/227514
Kind Code:
A1
Abstract:
Provided are an inert carrier indirect agglutination test detection system and an application thereof. Specifically, the indirect agglutination test detection system comprises an inert carrier bacteria S9 and a complex S9-P that expresses and carries a P antigen factor on the surface thereof. The inert carrier indirect agglutination test detection system only carries the P antigen factor, and has a positive particle agglutination reaction that is visible to the naked eye with the whole blood or serum of Salmonella pullorum and Salmonella gallinarum-infected chickens at certain concentration conditions, and has no non-specific cross-agglutination reactions with the serum or whole blood of different background chicken sources without Salmonella pullorum and Salmonella gallinarum infections. S9-P is based on a glass plate agglutination reaction operation platform. Agglutination reaction particles are visible to the naked eye, and the result is clear and easy to determine. The test and result determinations are complete within two minutes. S9-P is suitable for the targeted and specific detection of Salmonella pullorum and Salmonella gallinarum in chicken flocks, and has good application prospects in the field monitoring and diagnosis of chicken flocks.
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Inventors:
ZHU GUOQIANG (CN)
YANG BIN (CN)
YANG YANG (CN)
MENG XIA (CN)
XIA PENGPENG (CN)
DUAN QIANGDE (CN)
ZHU XIAOFANG (CN)
YANG BIN (CN)
YANG YANG (CN)
MENG XIA (CN)
XIA PENGPENG (CN)
DUAN QIANGDE (CN)
ZHU XIAOFANG (CN)
Application Number:
PCT/CN2020/140030
Publication Date:
November 18, 2021
Filing Date:
December 28, 2020
Export Citation:
Assignee:
UNIV YANGZHOU (CN)
International Classes:
G01N33/569; C07K14/255; C12N15/31; C12N15/74
Foreign References:
| CN111537712A | 2020-08-14 | |||
| CN110218668A | 2019-09-10 | |||
| CN109207417A | 2019-01-15 | |||
| CN104789500A | 2015-07-22 | |||
| US8771936B2 | 2014-07-08 |
Other References:
YANG WEIFENG: "Development of Monoclonal Antibody Against Salmonella PEG Fimrbrae and Preliminary Clinical Application", CHINESE MASTER’S THESES FULL-TEXT DATABASE, AGRICULTURE SCIENCE AND TECHNOLOGY, no. 2, 15 February 2017 (2017-02-15), XP055866946
YUE MIN, RANKIN SHELLEY C., BLANCHET RYAN T., NULTON JAMES D., EDWARDS ROBERT A., SCHIFFERLI DIETER M.: "Diversification of the Salmonella Fimbriae: A Model of Macro- and Microevolution", PLOS ONE, vol. 7, no. 6, 12 June 2012 (2012-06-12), pages e38596, XP055866945, DOI: 10.1371/journal.pone.0038596
YUE MIN, RANKIN SHELLEY C., BLANCHET RYAN T., NULTON JAMES D., EDWARDS ROBERT A., SCHIFFERLI DIETER M.: "Diversification of the Salmonella Fimbriae: A Model of Macro- and Microevolution", PLOS ONE, vol. 7, no. 6, 12 June 2012 (2012-06-12), pages e38596, XP055866945, DOI: 10.1371/journal.pone.0038596
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM(ORDINARY PARTNERSHIP) (CN)
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