Title:
INFECTIVE PROTEIN DELIVERY SYSTEM
Document Type and Number:
WIPO Patent Application WO1991006658
Kind Code:
A3
Abstract:
A DNA construct is provided comprising a first DNA encoding the gamma -interferon signal peptide linked to the 5' end of a second DNA encoding a human protein, e.g. a cytokine such as TNF, not naturally linked to said signal peptide, wherein said signal peptide has the property of augmenting the secretion of said human protein from a mammalian cell. Such a DNA construct may be a vector such as a retroviral vector. Also provided are virions carrying a DNA vector of the invention or a reverse transcript thereof.
Inventors:
KRIEGLER MICHAEL (US)
PEREZ CARL F (US)
PEREZ CARL F (US)
Application Number:
PCT/US1990/006141
Publication Date:
October 17, 1991
Filing Date:
October 23, 1990
Export Citation:
Assignee:
CETUS CORP (US)
International Classes:
A01N63/00; A61K9/50; A61K35/76; A61K38/00; A61K38/19; A61K38/21; A61K38/22; A61K48/00; C12N5/10; A61P35/00; C07K14/47; C07K14/525; C07K14/57; C12N5/08; C12N5/22; C12N7/00; C12N15/09; C12N15/19; C12N15/23; C12N15/28; C12N15/48; C12N15/867; C12P21/02; C12R1/91; C12R1/92; (IPC1-7): C12N15/86; C12N15/48; A61K37/02; C12N15/62; C12N15/28; C07K13/00; A61K47/00; C12N5/10
Foreign References:
| EP0243204A2 | 1987-10-28 | |||
| EP0334301A1 | 1989-09-27 | |||
| EP0317649A1 | 1989-05-31 | |||
| EP0196864A2 | 1986-10-08 |
Download PDF:
Previous Patent: RECOMBINANT DNA METHOD AND VECTORS FOR USE THEREIN
Next Patent: METHOD AND APPARATUS FOR THE DIAGNOSING OF VIRAL AND GENETIC DISEASES
Next Patent: METHOD AND APPARATUS FOR THE DIAGNOSING OF VIRAL AND GENETIC DISEASES