Title:
INFLAMMATORY MEDIATION OBTAINED FROM ATRACTYLODES LANCEA
Document Type and Number:
WIPO Patent Application WO2000056348
Kind Code:
A9
Abstract:
The present invention provides a method for inhibiting the activity of cyclooxygenase-2 and other proinflammatory factors in a mammal. The method comprises administering to the mammal a therapeutically effective or prophylactically effective amount of an organic extract of Atractylodes lancea. The inhibitory effect of the organic extract of this invention on cyclooxygenase-2 activity is substantially greater than the inhibitory effect of the organic extract on cyclooxygenase-1 activity. The present invention also provided a method for treating a mammal having, or at risk for developing, a condition which is benefited by the inhibition of cyclooxygenase-2 or other proinflammatory factors. The method comprises administering to the mammal a therapeutically effective or prophylactically effective amount of the organic extract of Atractylodes lancea.
Inventors:
CORLEY DAVID G (US)
OBUKOWICZ MARK (US)
OBUKOWICZ MARK (US)
Application Number:
PCT/US2000/007085
Publication Date:
June 27, 2002
Filing Date:
March 20, 2000
Export Citation:
Assignee:
PHARMACIA CORP (US)
CORLEY DAVID G (US)
OBUKOWICZ MARK (US)
CORLEY DAVID G (US)
OBUKOWICZ MARK (US)
International Classes:
A23L1/30; C12N9/99; A61K36/16; A61K36/28; A61K36/284; A61K36/68; A61K36/81; A61K36/8962; A61P19/02; A61P25/00; A61P29/00; A61P29/02; A61P35/00; A61P43/00; A61K; A61P; (IPC1-7): A61K35/78; A61P29/02
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