Title:
INFLUENZA VACCINE FOR TRANSNASAL ADMINISTRATION
Document Type and Number:
WIPO Patent Application WO/2022/210764
Kind Code:
A1
Abstract:
Provided is an influenza vaccine for transnasal administration which is efficiently taken up though the nasal mucosa. This influenza vaccine composition for transnasal administration contains an influenza antigen to which TGDK is linked via a chemical bond.
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Inventors:
MITSUMATA RYOTARO (JP)
MISUMI SHOGO (JP)
NAKATA NAGISA (JP)
KISHIMOTO NAOKI (JP)
MISUMI SHOGO (JP)
NAKATA NAGISA (JP)
KISHIMOTO NAOKI (JP)
Application Number:
PCT/JP2022/015639
Publication Date:
October 06, 2022
Filing Date:
March 29, 2022
Export Citation:
Assignee:
DENKA COMPANY LTD (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
A61K39/145; A61K9/08; A61K9/14; A61P31/16; C12N7/04
Domestic Patent References:
| WO2020067302A1 | 2020-04-02 | |||
| WO2007052641A1 | 2007-05-10 | |||
| WO2007052641A1 | 2007-05-10 | |||
| WO2013024859A1 | 2013-02-21 |
Foreign References:
| JP2013035817A | 2013-02-21 | |||
| JP2008231343A | 2008-10-02 |
Other References:
MITSUMATA RYOTAROU, ET AL.: "Tetragalloyl-D-Lysin Dendrimer improves the immunogenicity of intranasal Influenza vaccine", 13TH MEETING OF THE JAPANESE VACCINE ADJUVANT RESEARCH CONSORTIUM, vol. 13, 21 January 2020 (2020-01-21), XP055972268
S. MISUMI, M. MASUYAMA, N. TAKAMUNE, D. NAKAYAMA, R. MITSUMATA, H. MATSUMOTO, N. URATA, Y. TAKAHASHI, A. MUNEOKA, T. SUKAMOTO, K. : "Targeted Delivery of Immunogen to Primate M Cells with Tetragalloyl Lysine Dendrimer", THE JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, vol. 182, no. 10, 15 May 2009 (2009-05-15), pages 6061 - 6070, XP055036259, ISSN: 00221767, DOI: 10.4049/jimmunol.0802928
MOSSAD SB.: "Demystifying FluMist, a new intranasal, live influenza vaccine.", CLEVE CLIN J MED., vol. 70, no. 9, September 2003 (2003-09-01), pages 801 - 6
AINAI ATAMURA SSUZUKI T ET AL.: "Intranasal vaccination with an inactivated whole influenza virus vaccine induces strong antibody responses in serum and nasal mucus of healthy adults.", HUM VACCIN IMMUNOTHER., vol. 9, no. 9, September 2013 (2013-09-01), pages 1962 - 70, XP055433271, DOI: 10.4161/hv.25458
MISUMI SMASUYAMA MTAKAMUNE N ET AL.: "Targeted Delivery of Immunogen to Primate M Cells with Tetragalloyl Lysine Dendrimer", JOURNAL OF IMMUNOLOGY, vol. 182, no. 10, 2009, pages 6061 - 6070, XP055036259, DOI: 10.4049/jimmunol.0802928
KAI HMOTOMURA YSAITO SYAMAMOTO KTATEFUCHI TTAKAMUNE NMISUMI S: "Royal jelly enhances antigen-specific IgA response.", FOOD SCI NUTR., vol. 1, no. 3, 6 March 2013 (2013-03-06), pages 222 - 227, XP055689695, DOI: 10.1002/fsn3.29
S. MISUMI, M. MASUYAMA, N. TAKAMUNE, D. NAKAYAMA, R. MITSUMATA, H. MATSUMOTO, N. URATA, Y. TAKAHASHI, A. MUNEOKA, T. SUKAMOTO, K. : "Targeted Delivery of Immunogen to Primate M Cells with Tetragalloyl Lysine Dendrimer", THE JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, vol. 182, no. 10, 15 May 2009 (2009-05-15), pages 6061 - 6070, XP055036259, ISSN: 00221767, DOI: 10.4049/jimmunol.0802928
MOSSAD SB.: "Demystifying FluMist, a new intranasal, live influenza vaccine.", CLEVE CLIN J MED., vol. 70, no. 9, September 2003 (2003-09-01), pages 801 - 6
AINAI ATAMURA SSUZUKI T ET AL.: "Intranasal vaccination with an inactivated whole influenza virus vaccine induces strong antibody responses in serum and nasal mucus of healthy adults.", HUM VACCIN IMMUNOTHER., vol. 9, no. 9, September 2013 (2013-09-01), pages 1962 - 70, XP055433271, DOI: 10.4161/hv.25458
MISUMI SMASUYAMA MTAKAMUNE N ET AL.: "Targeted Delivery of Immunogen to Primate M Cells with Tetragalloyl Lysine Dendrimer", JOURNAL OF IMMUNOLOGY, vol. 182, no. 10, 2009, pages 6061 - 6070, XP055036259, DOI: 10.4049/jimmunol.0802928
KAI HMOTOMURA YSAITO SYAMAMOTO KTATEFUCHI TTAKAMUNE NMISUMI S: "Royal jelly enhances antigen-specific IgA response.", FOOD SCI NUTR., vol. 1, no. 3, 6 March 2013 (2013-03-06), pages 222 - 227, XP055689695, DOI: 10.1002/fsn3.29
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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