INFLUENZA VIRUS NEURAMINIDASE MUTANT, NUCLEIC ACID MOLECULE ENCODING INFLUENZA VIRUS NEURAMINIDASE MUTANT, VACCINE COMPOSITION COMPRISING INFLUENZA VIRUS NEURAMINIDASE MUTANT, AND USE OF INFLUENZA VIRUS NEURAMINIDASE MUTANT IN PREPARATION OF INFLUENZA VIRUS VACCINE COMPOSITION

Title:

Document Type and Number:

WIPO Patent Application WO/2024/078631

Kind Code:

A1

Abstract:

Provided are an influenza virus neuraminidase mutant, a nucleic acid molecule encoding the influenza virus neuraminidase mutant, a vaccine composition comprising the influenza virus neuraminidase mutant, and a use of the influenza virus neuraminidase mutant in the preparation of an influenza virus vaccine composition. Through various efficacy experiments, the vaccine composition achieves the effect of preventing influenza virus infection.

Inventors:

WU SUH-CHIN (CN)
CHANG CHIA-HAO (CN)
HUNG HAO-CHAN (CN)
LIN WEI-SHUO (CN)

Application Number:

PCT/CN2023/124604

Publication Date:

April 18, 2024

Filing Date:

October 13, 2023

Export Citation:

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Assignee:

WU SUH CHIN (CN)

International Classes:

C12N9/24; A61K39/145; A61P31/16; C12N7/01

Foreign References:

CN105400753A	2016-03-16
CN101983069A	2011-03-02
US5962298A	1999-10-05
US20160287692A1	2016-10-06

Other References:

CHU, FULU ET AL.: "Role of N-linked glycosylation of the human parainfluenza virus type 3 hemagglutinin-neuraminidase protein", VIRUS RESEARCH, 3 April 2013 (2013-04-03), pages 137 - 147, XP028533805, DOI: 10.1016/j.virusres.2013.03.012
ZHENG QIN-MEI: "Progress on Neuraminidase Protein Function of Influenza A Virus ", PROGRESS IN VETERINARY MEDICINE, vol. 42, no. 10, 20 October 2021 (2021-10-20), pages 66 - 72, XP093159344, DOI: 10.16437/j.cnki.1007-5038.2021.10.012

Attorney, Agent or Firm:

DRAGON INTELLECTUAL PROPERTY LAW FIRM (CN)

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