Title:
INFLUENZA VIRUS NEUTRALIZING ANTIBODY AND METHOD FOR SCREENING SAME
Document Type and Number:
WIPO Patent Application WO/2012/029997
Kind Code:
A1
Abstract:
The present invention provides an anti-influenza virus antibody that has neutralizing activity against any of the influenza viruses which are categorized into two groups by degree of amino acid conservation in hemagglutinin, regardless of any differences between the groups. The present invention also provides a method for producing the same, and a method for testing whether a subject has the neutralizing antibody.
Inventors:
KUROSAWA YOSHIKAZU (JP)
IBA YOSHITAKA (JP)
OHSHIMA NOBUKO (JP)
OKUNO YOSHINOBU (JP)
IBA YOSHITAKA (JP)
OHSHIMA NOBUKO (JP)
OKUNO YOSHINOBU (JP)
Application Number:
PCT/JP2011/070544
Publication Date:
March 08, 2012
Filing Date:
September 02, 2011
Export Citation:
Assignee:
UNIV FUJITA HEALTH (JP)
UNIV OSAKA RES FOUND (JP)
KUROSAWA YOSHIKAZU (JP)
IBA YOSHITAKA (JP)
OHSHIMA NOBUKO (JP)
OKUNO YOSHINOBU (JP)
UNIV OSAKA RES FOUND (JP)
KUROSAWA YOSHIKAZU (JP)
IBA YOSHITAKA (JP)
OHSHIMA NOBUKO (JP)
OKUNO YOSHINOBU (JP)
International Classes:
C12N15/09; A61K39/145; A61K39/42; A61P31/16; C07K16/10
Domestic Patent References:
| WO2010010467A2 | 2010-01-28 | |||
| WO2008028946A2 | 2008-03-13 | |||
| WO2009079259A2 | 2009-06-25 | |||
| WO2001062907A1 | 2001-08-30 | |||
| WO2007134327A2 | 2007-11-22 | |||
| WO2008028946A2 | 2008-03-13 |
Foreign References:
| USPP38005110P | 2010-09-03 | |||
| USPP45278511P | ||||
| US201113198147A | 2011-08-04 |
Other References:
YOSHIDA R. ET AL.: "Cross-Protective Potential of a Novel Monoclonal Antibody Directed against Antigenic Site B of the Hemagglutinin of Influenza A Viruses. art. e1000350", PLOS PATHOGENS, vol. 5, no. 3, March 2009 (2009-03-01), pages 1 - 9, XP002541080
YAMASHITA, A. ET AL.: "Highly conserved sequences for human neutralization epitope on hemagglutinin of influenza A viruses H3N2, H1N1 and H5Nl: Implication for human monoclonal antibody recognition.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 393, February 2010 (2010-02-01), pages 614 - 618, XP026970727
YOSHINOBU OKUNO ET AL.: "Influenza Vaccine Kabu o Mochiita Hito Monoclone Kotai no Seijo Kaiseki", CHORYOYAKU TO SHITE NO HITO KOTAI SEIZAIKA NI KANSURU KENKYU, HEISEI 18 NENDO SOKATSU - BUNTAN KENKYU HOKOKUSHO, 2007, pages 8 - 20
See also references of EP 2626425A4
VIROLOGY, vol. 397, 2010, pages 322 - 330
PROC. NATL. ACAD. SCI. USA., vol. 105, 2008, pages 5986 - 5991
PLOS ONE, vol. 3, 2008, pages 5986 - 5991
NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 16, 2009, pages 265 - 273
SCIENCE, vol. 324, 2009, pages 246 - 251
NATURE, vol. 289, 1981, pages 373 - 378
J. GEN. VIROL., vol. 62, 1982, pages 153 - 169
HOLT ET AL., CURR. OPIN. BIOTECHNOL., vol. 11, 2000, pages 445 - 449
J. BIOL. CHEM., vol. 274, 1999, pages 18218 - 18230
J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
NAT. BIOTECHNOL., vol. 14, 1996, pages 309 - 314
ANNU. REV. IMMUNOL., vol. 12, 1994, pages 433 - 455
J. BIOL. CHEM., 1999
PROC. NATL. ACAD. SCI. USA, vol. 14, 2000, pages 7969 - 7974
J. MOL. BIOL., vol. 296, 2000, pages 57 - 86
NAT. BIOTECHNOL., vol. 18, 2000, pages 852
PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 3938
J. IMMUNOL. METHODS, vol. 272, 2003, pages 219 - 233
PLOS MEDICINE, vol. 4, no. 5, 2007, pages 0928 - 9936
NATURE, vol. 256, 1975, pages 495
J. CLIN. MICROBIOL., vol. 28, 1990, pages 1308 - 1313
NATURE, vol. 333, 1988, pages 426 - 431
P.A. UNDERWOOD, J. GEN. VIROL., vol. 62, 1982, pages 153 - 169
WILEY ET AL., NATURE, vol. 289, 1981, pages 366 - 378
MAMORU NAKANISHI ET AL., PROTEIN, NUCLEIC ACID AND ENZYME, vol. 44, 1999, pages 1590 - 1596
SHIROH FUTAKI, KAGAKU TO SEIBUTSU, vol. 43, 2005, pages 649 - 653
CLINICAL CANCER RESEARCH, vol. 59, 1999, pages 4325 - 4333
NAT. STRUCT. MOL. BIOL., vol. 16, 2009, pages 265 - 273
PLOS ONE, vol. 3, 2008, pages E3942
PNAS, vol. 105, 2008, pages 5986 - 5991
OKADA ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 92, 2011, pages 326 - 335
YAMASHITA, A. ET AL.: "Highly conserved sequences for human neutralization epitope on hemagglutinin of influenza A viruses H3N2, H1N1 and H5Nl: Implication for human monoclonal antibody recognition.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 393, February 2010 (2010-02-01), pages 614 - 618, XP026970727
YOSHINOBU OKUNO ET AL.: "Influenza Vaccine Kabu o Mochiita Hito Monoclone Kotai no Seijo Kaiseki", CHORYOYAKU TO SHITE NO HITO KOTAI SEIZAIKA NI KANSURU KENKYU, HEISEI 18 NENDO SOKATSU - BUNTAN KENKYU HOKOKUSHO, 2007, pages 8 - 20
See also references of EP 2626425A4
VIROLOGY, vol. 397, 2010, pages 322 - 330
PROC. NATL. ACAD. SCI. USA., vol. 105, 2008, pages 5986 - 5991
PLOS ONE, vol. 3, 2008, pages 5986 - 5991
NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 16, 2009, pages 265 - 273
SCIENCE, vol. 324, 2009, pages 246 - 251
NATURE, vol. 289, 1981, pages 373 - 378
J. GEN. VIROL., vol. 62, 1982, pages 153 - 169
HOLT ET AL., CURR. OPIN. BIOTECHNOL., vol. 11, 2000, pages 445 - 449
J. BIOL. CHEM., vol. 274, 1999, pages 18218 - 18230
J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
NAT. BIOTECHNOL., vol. 14, 1996, pages 309 - 314
ANNU. REV. IMMUNOL., vol. 12, 1994, pages 433 - 455
J. BIOL. CHEM., 1999
PROC. NATL. ACAD. SCI. USA, vol. 14, 2000, pages 7969 - 7974
J. MOL. BIOL., vol. 296, 2000, pages 57 - 86
NAT. BIOTECHNOL., vol. 18, 2000, pages 852
PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 3938
J. IMMUNOL. METHODS, vol. 272, 2003, pages 219 - 233
PLOS MEDICINE, vol. 4, no. 5, 2007, pages 0928 - 9936
NATURE, vol. 256, 1975, pages 495
J. CLIN. MICROBIOL., vol. 28, 1990, pages 1308 - 1313
NATURE, vol. 333, 1988, pages 426 - 431
P.A. UNDERWOOD, J. GEN. VIROL., vol. 62, 1982, pages 153 - 169
WILEY ET AL., NATURE, vol. 289, 1981, pages 366 - 378
MAMORU NAKANISHI ET AL., PROTEIN, NUCLEIC ACID AND ENZYME, vol. 44, 1999, pages 1590 - 1596
SHIROH FUTAKI, KAGAKU TO SEIBUTSU, vol. 43, 2005, pages 649 - 653
CLINICAL CANCER RESEARCH, vol. 59, 1999, pages 4325 - 4333
NAT. STRUCT. MOL. BIOL., vol. 16, 2009, pages 265 - 273
PLOS ONE, vol. 3, 2008, pages E3942
PNAS, vol. 105, 2008, pages 5986 - 5991
OKADA ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 92, 2011, pages 326 - 335
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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