Title:
INFLUENZA VIRUS SURFACE PROTEIN-DERIVED RECOMBINANT HEMAGGLUTININ PROTEIN FORMING TRIMER, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/215855
Kind Code:
A1
Abstract:
The present invention relates to an influenza virus surface protein-derived recombinant hemagglutinin (HA) protein forming a trimer, and a use thereof, and, specifically, to: a recombinant vector for producing an influenza virus surface protein-derived HA protein forming a trimer; a transformant transformed with the recombinant vector; a method for producing the influenza virus surface protein-derived HA protein forming a trimer, by using the recombinant vector; the influenza virus surface protein-derived HA protein forming a trimer, produced by the method; and a use thereof for preventing, alleviating, or treating influenza virus infection diseases.
Inventors:
HWANG IN HWAN (KR)
LEE JUN HO (KR)
HAIPING DIAO (KR)
SONG SHIJIAN (KR)
KIM WOE YEON (KR)
KIM MIN GAB (KR)
RYU GYEONG RYUL (KR)
SHIN GYEONG IM (KR)
SONG CHANG SEON (KR)
LEE JI HO (KR)
KIM DEOK HWAN (KR)
LEE JUN HO (KR)
HAIPING DIAO (KR)
SONG SHIJIAN (KR)
KIM WOE YEON (KR)
KIM MIN GAB (KR)
RYU GYEONG RYUL (KR)
SHIN GYEONG IM (KR)
SONG CHANG SEON (KR)
LEE JI HO (KR)
KIM DEOK HWAN (KR)
Application Number:
PCT/KR2021/005119
Publication Date:
October 28, 2021
Filing Date:
April 22, 2021
Export Citation:
Assignee:
POSTECH ACAD IND FOUND (KR)
BIOAPPLICATIONS INC (KR)
NAT UNIV GYEONGSANG IACF (KR)
UNIV KONKUK IND COOP CORP (KR)
BIOAPPLICATIONS INC (KR)
NAT UNIV GYEONGSANG IACF (KR)
UNIV KONKUK IND COOP CORP (KR)
International Classes:
C12N15/82; C07K14/005
Domestic Patent References:
| WO2012128628A1 | 2012-09-27 |
Foreign References:
| US20130004547A1 | 2013-01-03 | |||
| EP0120516A2 | 1984-10-03 | |||
| US4940838A | 1990-07-10 |
Other References:
YOKO SHOJI, R. MARK JONES, VADIM METT, JESSICA A. CHICHESTER, KONSTANTIN MUSIYCHUK, XIANGJIE SUN, TERRENCE M. TUMPEY, BRIAN J. GRE: "A plant-produced H1N1 trimeric hemagglutinin protects mice from a lethal influenza virus challenge", HUMAN VACCINES & IMMUNOTHERAPEUTICS, TAYLOR & FRANCIS, US, vol. 9, no. 3, 18 March 2013 (2013-03-18), US , pages 553 - 560, XP055283062, ISSN: 2164-5515, DOI: 10.4161/hv.23234
JEE PUI-FONG, CHEN FEZ-SHIN, SHU MENG-HOOI, WONG WON FEN, ABDUL RAHIM RAHA, ABUBAKAR SAZALY, CHANG LI-YEN: "Insertion of single-chain variable fragment (scFv) peptide linker improves surface display of influenza hemagglutinin (HA1) on non-recombinant Lactococcus lactis", BIOTECHNOLOGY PROGRESS, AMERICAN CHEMICAL SOCIETY, vol. 33, no. 1, 1 January 2017 (2017-01-01), pages 154 - 162, XP055859545, ISSN: 8756-7938, DOI: 10.1002/btpr.2400
DATABASE PROTEIN 26 January 2015 (2015-01-26), ANONYMOUS : "hemagglutinin [Influenza A virus (A/chicken/Shenzhen/433/2013(H5N6))] ", XP055859546, retrieved from NCBI Database accession no. AJD09950
"GenBank", Database accession no. AFM47147.1
See also references of EP 4141121A1
JEE PUI-FONG, CHEN FEZ-SHIN, SHU MENG-HOOI, WONG WON FEN, ABDUL RAHIM RAHA, ABUBAKAR SAZALY, CHANG LI-YEN: "Insertion of single-chain variable fragment (scFv) peptide linker improves surface display of influenza hemagglutinin (HA1) on non-recombinant Lactococcus lactis", BIOTECHNOLOGY PROGRESS, AMERICAN CHEMICAL SOCIETY, vol. 33, no. 1, 1 January 2017 (2017-01-01), pages 154 - 162, XP055859545, ISSN: 8756-7938, DOI: 10.1002/btpr.2400
DATABASE PROTEIN 26 January 2015 (2015-01-26), ANONYMOUS : "hemagglutinin [Influenza A virus (A/chicken/Shenzhen/433/2013(H5N6))] ", XP055859546, retrieved from NCBI Database accession no. AJD09950
"GenBank", Database accession no. AFM47147.1
See also references of EP 4141121A1
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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