Title:
INHALABLE AROMATIC RING THIAZIDE AND ANALOG, PHARMACEUTICAL COMPOSITION CONTAINING INHALABLE AROMATIC RING THIAZINE, AND USE OF INHALABLE AROMATIC RING THIAZINE IN ANTI-INFLAMMATION AND ANTI-TUMOR
Document Type and Number:
WIPO Patent Application WO/2024/099478
Kind Code:
A1
Abstract:
A selective inhibitor of PI3Kδ, and a free base, isomer, solvate, pharmaceutically acceptable salt and other structural forms thereof. The compounds have significant antagonistic activity on PI3Kδ, and a pharmacokinetic study shows that some of the compounds have a high plasma clearance rate and low oral bioavailability, such that the compounds are suitable for being developed as inhalable drugs for the prevention or treatment of diseases associated with the kinase activity and abnormal expression of PI3Kδ, especially respiratory diseases such as asthma and COPD.
Inventors:
SHENG RONG (CN)
LOU JINFANG (CN)
WEI JUN (CN)
FENG ENGUANG (CN)
LOU JINFANG (CN)
WEI JUN (CN)
FENG ENGUANG (CN)
Application Number:
PCT/CN2024/071470
Publication Date:
May 16, 2024
Filing Date:
January 09, 2024
Export Citation:
Assignee:
HANGZHOU BIO SINCERITY PHARMA TECH CO LTD (CN)
International Classes:
C07D417/12; A61K31/5415; A61K31/542; A61P11/00; A61P11/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; C07D417/14; C07D513/04
Foreign References:
| CN117088867A | 2023-11-21 | |||
| CN107033145A | 2017-08-11 | |||
| CN101031569A | 2007-09-05 | |||
| CN106008479A | 2016-10-12 | |||
| CN106366085A | 2017-02-01 |
Attorney, Agent or Firm:
HANGZHOU KAIZHI PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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