Title:
INHALANT COMPRISING MODIFIED SUPEROXIDE DISMUTASE
Document Type and Number:
WIPO Patent Application WO/2010/064522
Kind Code:
A1
Abstract:
Disclosed is an inhalant particularly for treating idiopathic (acute) or chronic interstitial pneumonia, which comprises, as an active ingredient, a lecithin-bound superoxide dismutase (PC-SOD) that can exert the activity of a superoxide dismutase (SOD) efficiently. Specifically disclosed is an inhalant characterized by comprising, as an active ingredient, a PC-SOD represented by general formula (I):
SOD'(Q-B)m (I)
(In the formula, SOD' represents a residue of a superoxide dismutase; Q represents a chemical cross-linkage; B represents a residue produced by removing an hydrogen atom from a hydroxy group in lysolecithin having the hydroxy group at position-2 in a glycerol moiety thereof; and m represents an average number of lysolecithin molecules bound to one superoxide dismutase molecule and is an integer of 1 or greater.)
Inventors:
MIZUSHIMA TORU (JP)
Application Number:
PCT/JP2009/069067
Publication Date:
June 10, 2010
Filing Date:
November 09, 2009
Export Citation:
Assignee:
LTT BIO PHARMA CO LTD (JP)
MIZUSHIMA TORU (JP)
MIZUSHIMA TORU (JP)
International Classes:
A61K38/44; A61K9/10; A61K9/14; A61K9/72; A61K47/26; A61K47/48; A61P11/00
Foreign References:
| JP2001002585A | 2001-01-09 | |||
| JP2003513048A | 2003-04-08 | |||
| JP2001064199A | 2001-03-13 | |||
| JPH09117279A | 1997-05-06 | |||
| JPH0952843A | 1997-02-25 | |||
| JPH0959178A | 1997-03-04 | |||
| JPH09110717A | 1997-04-28 | |||
| JPH10338645A | 1998-12-22 | |||
| JP2001002585A | 2001-01-09 | |||
| JP2001151695A | 2001-06-05 | |||
| JP2006169128A | 2006-06-29 | |||
| JP2001064199A | 2001-03-13 | |||
| JPH09117279A | 1997-05-06 |
Other References:
YASUO MATSUZAWA ET AL.: "Kosanka Ryoho -Saikin no Topics SOD/Shokaki Shikkan/Hai Shikkan", INFLAMMATION & IMMUNOLOGY 0918-8371, vol. 16, no. 5, 20 August 2008 (2008-08-20), pages 41 - 46, XP008168438
TOMOHIKO NAKAMURA: "Mansei Hai Shikkan Hassho Yobo no Tameno Kei Kidoteki Chiryo no Kanosei", JOURNAL OF JAPAN SOCIETY FOR PREMATURE AND NEWBORN MEDICINE 1347-8540, vol. 17, no. 3, 2005, pages 391, XP008168341
J. BIOL. CHEM., vol. 244, no. 22, 1969, pages 6049 - 6055
See also references of EP 2359845A4
TOMOHIKO NAKAMURA: "Mansei Hai Shikkan Hassho Yobo no Tameno Kei Kidoteki Chiryo no Kanosei", JOURNAL OF JAPAN SOCIETY FOR PREMATURE AND NEWBORN MEDICINE 1347-8540, vol. 17, no. 3, 2005, pages 391, XP008168341
J. BIOL. CHEM., vol. 244, no. 22, 1969, pages 6049 - 6055
See also references of EP 2359845A4
Attorney, Agent or Firm:
KUSAMA, OSAMU (JP)
Osamu Kusama (JP)
Osamu Kusama (JP)
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