Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
INHIBITION OF DYRK1A KINASE
Document Type and Number:
WIPO Patent Application WO/2022/051291
Kind Code:
A3
Abstract:
Novel compounds which inhibit DYRK1A activity comprise thymoquinone derivatives including a pair of substituted or unsubstituted six-membered carbon rings selected from phenyl and cyclohexadiene linked by an alkyl or alkenyl linker. Each six-membered ring includes at least one oxygen-bearing substituent selected from carbonyl oxygens, hydroxyls, alkoxyls, and halogenated derivatives thereof. The compounds can be administered to mammalian subjects for inhibition of DYRK1A kinase proteins.

Inventors:
ZAID GENE H (US)
BLAGG BRIAN SCOTT JOHNATHAN (US)
WEST CAMERON E (US)
Application Number:
PCT/US2021/048489
Publication Date:
May 05, 2022
Filing Date:
August 31, 2021
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
ANKH LIFE SCIENCES LTD (IE)
CROW LARRY D (US)
International Classes:
A61K31/045; A61K31/05; C07C39/02; C07C39/08
Foreign References:
JP2017149658A2017-08-31
US20190062284A12019-02-28
US20130225674A12013-08-29
US20170252318A12017-09-07
Attorney, Agent or Firm:
COOK, Crissa A. (US)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: CONNECTED MACHINE-LEARNING MODELS WITH JOINT TRAINING FOR LESION DETECTION

Next Patent: COMPOSITE PRODUCT, COMPOSITE PRODUCT PRODUCTION SYSTEM, COMPOSITE PRODUCT PRODUCTION PROCESS, AND SY...