Title:
INHIBITION OF SELECTED TUMOR GROWTH WITH RECOMBINANT VIRAL SECTOR
Document Type and Number:
WIPO Patent Application WO1994021792
Kind Code:
A3
Abstract:
The present invention provides methods for inhibiting the growth of selected tumors utilizing recombinant viral vectors. Briefly, within one aspect of the present invention, a method for inhibiting the growth of a selected tumor is provided comprising the step of directly administering to a warm-blooded animal a vector construct which directs the expression of at least one anti-tumor agent, such that the growth of said tumor is inhibited. Representative examples of anti-tumor agents include immune activators and tumor proliferation inhibitors.
Inventors:
BARBER JACK R
JOLLY DOUGLAS J
RESPESS JAMES G
JOLLY DOUGLAS J
RESPESS JAMES G
Application Number:
PCT/US1994/002951
Publication Date:
January 05, 1995
Filing Date:
March 17, 1994
Export Citation:
Assignee:
VIAGENE INC (US)
International Classes:
C12N15/09; A01K67/027; A01K67/033; A61K35/76; A61K38/00; A61K38/16; A61K38/20; A61K38/21; A61K38/46; A61K39/00; A61K45/00; A61K48/00; A61P35/00; C07H21/04; C07K14/15; C07K14/155; C07K14/16; C07K14/55; C07K14/57; C07K14/73; C07K14/735; C12N5/10; C12N7/04; C12N9/12; C12N15/23; C12N15/85; C12N15/867; A61K35/13; (IPC1-7): C12N15/23; A61K48/00; C12N15/26; C12N15/62; C12N5/10; C12N15/13; A61K37/02
Domestic Patent References:
| WO1993021959A1 | 1993-11-11 | |||
| WO1994004196A1 | 1994-03-03 | |||
| WO1993006867A1 | 1993-04-15 | |||
| WO1993010814A1 | 1993-06-10 | |||
| WO1993019191A1 | 1993-09-30 | |||
| WO1993010219A1 | 1993-05-27 | |||
| WO1994013824A1 | 1994-06-23 |
Foreign References:
| EP0206920A1 | 1986-12-30 |
Other References:
CULVER, K.W. ET AL.: "In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors", SCIENCE, vol. 256, no. 5063, 12 June 1992 (1992-06-12), LANCASTER, PA US, pages 1550 - 1552
PANIS, Y. ET AL.: "Traitement des tumeurs hépatiques expérimentales par transfert de gène suicide in vivo vhez le rat", COMPTES RENDUS DE L'ACADEMIE DES SCIENCES : SERIE III, vol. 315, 1992, MONTREUIL FR, pages 541 - 544
CARUSO, M. ET AL.: "Regression of established macroscopic liver metastases after in situ transduction of a suicide gene", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 90, August 1993 (1993-08-01), WASHINGTON US, pages 7024 - 7028
"Chambers science and technology dictionary", WALKER, P. M. B., CAMBRIDGE UK
PANIS, Y. ET AL.: "Traitement des tumeurs hépatiques expérimentales par transfert de gène suicide in vivo vhez le rat", COMPTES RENDUS DE L'ACADEMIE DES SCIENCES : SERIE III, vol. 315, 1992, MONTREUIL FR, pages 541 - 544
CARUSO, M. ET AL.: "Regression of established macroscopic liver metastases after in situ transduction of a suicide gene", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 90, August 1993 (1993-08-01), WASHINGTON US, pages 7024 - 7028
"Chambers science and technology dictionary", WALKER, P. M. B., CAMBRIDGE UK
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