Title:
INHIBITOR OF DOWNREGULATION OF CD39 GENE
Document Type and Number:
WIPO Patent Application WO/2022/045261
Kind Code:
A1
Abstract:
The present invention addresses the problem of developing of a drug capable of inhibiting downregulation of a CD39 gene involved in activation of Langerhans cells and modulating an immune response of the skin. The invention is based on the discovery that a composition that includes carboxymethyl beta-glucan or a salt thereof, polyoxyethylene (POE)-polyoxypropylene (POP) random copolymer dimethyl ether, and camellia extract inhibits downregulation of a CD39 gene by testosterone.
Inventors:
HOSOI JUNICHI (JP)
Application Number:
PCT/JP2021/031403
Publication Date:
March 03, 2022
Filing Date:
August 26, 2021
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
International Classes:
A61K36/82; A61K8/73; A61K8/86; A61K8/9789; A61K31/716; A61K31/717; A61K31/77; A61P17/00; A61P37/06; A61P43/00; A61Q19/00; C12N15/12; C12Q1/6851; C12Q1/686
Foreign References:
| JP2017511790A | 2017-04-27 | |||
| JP2015134737A | 2015-07-27 | |||
| JP2009155317A | 2009-07-16 | |||
| JP2000236775A | 2000-09-05 |
Other References:
KOYAMA YOH-ICHI, NAGAO SHIZUKO, OHASHI KOJI, TAKAHASHI HISAHIDE, MARUNOUCHI TOHRU: "Effect of Systemic and Topical Application of Testosterone Propionate on the Density of Epidermal Langerhans Cells in the Mouse", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 92, no. 1, 1 January 1989 (1989-01-01), NL , pages 86 - 90, XP055903280, ISSN: 0022-202X, DOI: 10.1111/1523-1747.ep13071282
HOSOI, JUNICHI: "An affectionate approach of skin care that takes advantage of the defense power", FRAGRANCE JOURNAL, vol. 46, no. 1, 1 January 2018 (2018-01-01), JP , pages 16 - 20, XP009534358, ISSN: 0288-9803
HOSOI, JUNICHI: "An affectionate approach of skin care that takes advantage of the defense power", FRAGRANCE JOURNAL, vol. 46, no. 1, 1 January 2018 (2018-01-01), JP , pages 16 - 20, XP009534358, ISSN: 0288-9803
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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