Title:
INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1
Document Type and Number:
WIPO Patent Application WO/2009/123241
Kind Code:
A1
Abstract:
Disclosed is a novel compound having an inhibitory activity on a plasminogen activator inhibitor-1 (PAI-1). Also disclosed is a PAI-1 inhibitor comprising the compound as an active ingredient. Further disclosed is a pharmaceutical composition effective for the prevention or treatment of various diseases whose occurrence is associated with a PAI-1 activity. The pharmaceutical composition comprises the compound having an inhibitory activity on a PAI-1 as an active ingredient. The novel compound has a basic skeleton represented by the formula. In the formula, B represents a carboxylic acid or a biological equivalent group thereof.
Inventors:
MIYATA TOSHIO (JP)
YAMAOKA NAGAHISA (JP)
KODAMA HIDEHIKO (JP)
MURANO KENJI (JP)
YAMAOKA NAGAHISA (JP)
KODAMA HIDEHIKO (JP)
MURANO KENJI (JP)
Application Number:
PCT/JP2009/056755
Publication Date:
October 08, 2009
Filing Date:
March 31, 2009
Export Citation:
Assignee:
RENASCIENCE CO LTD (JP)
MIYATA TOSHIO (JP)
YAMAOKA NAGAHISA (JP)
KODAMA HIDEHIKO (JP)
MURANO KENJI (JP)
MIYATA TOSHIO (JP)
YAMAOKA NAGAHISA (JP)
KODAMA HIDEHIKO (JP)
MURANO KENJI (JP)
International Classes:
C07C235/74; A61K31/167; A61K31/196; A61K31/245; A61K31/34; A61K31/36; A61K31/385; A61K31/40; A61K31/415; A61K31/42; A61K31/421; A61K31/4409; A61K31/47; A61P3/10; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P11/00; A61P13/12; A61P25/00; A61P27/02; A61P43/00; C07C231/02; C07C231/12; C07C319/20; C07C323/60; C07D207/325; C07D213/40; C07D213/74; C07D215/12; C07D231/12; C07D261/08; C07D263/32; C07D307/38; C07D307/79; C07D317/50; C07D333/06
Domestic Patent References:
| WO2007083689A1 | 2007-07-26 | |||
| WO2006107719A2 | 2006-10-12 | |||
| WO2009013915A1 | 2009-01-29 | |||
| WO2009013915A1 | 2009-01-29 |
Foreign References:
| JP2000290252A | 2000-10-17 | |||
| JP2007022943A | 2007-02-01 | |||
| JP2005275352A | 2005-10-06 | |||
| JPS567716A | 1981-01-27 |
Other References:
See also references of EP 2272822A4
AYA N. ET AL., J. PATHOL., vol. 166, 1992, pages 289 - 295
YOSHIDA Y. ET AL., NEPHRON, vol. 88, 2001, pages 24 - 29
W. A. BORDER ET AL., J. CLIN. INVEST., vol. 112, 2003, pages 379
W. A. BORDER ET AL., KIDNEY INT, vol. 59, 2001, pages 246
EGELUND R. ET AL., J. BIOL. CHEM., vol. 276, 2001, pages 13077 - 13086
D T EITZMAN ET AL., J. CLIN. INVEST., vol. 97, 1996, pages 232 - 237
JACOBSEN JS ET AL., PROC NATL ACAD SCI USA, vol. 105, no. 25, 16 June 2008 (2008-06-16), pages 8754 - 9
KOHARA ET AL., J. MED. CHEM., vol. 39, 1996, pages 5228 - 5235
MATSUO, O. ET AL., HAEMOSTASIS, vol. 16, 1986, pages 43 - 50
KIVIRIKKO ET AL., ANAL. BIOCHEM., vol. 19, 1967, pages 249 - 255
ASHCORT ET AL., J. CLIN. PATHOL., vol. 41, 1988, pages 467 - 470
J. CLIN. INVEST., vol. 97, 1996, pages 232 - 237
THROMB. HAEMOST., vol. 93, no. 4, April 2005 (2005-04-01), pages 631 - 640
AM. J. PATHOL., vol. 164, no. 2, February 2004 (2004-02-01), pages 449 - 456
TRENDS CARDIOVASC. MED., vol. 14, no. 5, July 2004 (2004-07-01), pages 196 - 202
J. HEPATOL., vol. 31, no. 4, October 1999 (1999-10-01), pages 703 - 711
J. LAB. CLIN. MED., vol. 144, no. 2, August 2004 (2004-08-01), pages 69 - 77
ONCOGENE, vol. 22, no. 28, 10 July 2003 (2003-07-10), pages 4389 - 4397
AM. J. PATHOL., vol. 172, no. 3, March 2008 (2008-03-01), pages 691 - 701
JACOBSEN JS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 105, no. 25, 2008, pages 8754 - 8759
AYA N. ET AL., J. PATHOL., vol. 166, 1992, pages 289 - 295
YOSHIDA Y. ET AL., NEPHRON, vol. 88, 2001, pages 24 - 29
W. A. BORDER ET AL., J. CLIN. INVEST., vol. 112, 2003, pages 379
W. A. BORDER ET AL., KIDNEY INT, vol. 59, 2001, pages 246
EGELUND R. ET AL., J. BIOL. CHEM., vol. 276, 2001, pages 13077 - 13086
D T EITZMAN ET AL., J. CLIN. INVEST., vol. 97, 1996, pages 232 - 237
JACOBSEN JS ET AL., PROC NATL ACAD SCI USA, vol. 105, no. 25, 16 June 2008 (2008-06-16), pages 8754 - 9
KOHARA ET AL., J. MED. CHEM., vol. 39, 1996, pages 5228 - 5235
MATSUO, O. ET AL., HAEMOSTASIS, vol. 16, 1986, pages 43 - 50
KIVIRIKKO ET AL., ANAL. BIOCHEM., vol. 19, 1967, pages 249 - 255
ASHCORT ET AL., J. CLIN. PATHOL., vol. 41, 1988, pages 467 - 470
J. CLIN. INVEST., vol. 97, 1996, pages 232 - 237
THROMB. HAEMOST., vol. 93, no. 4, April 2005 (2005-04-01), pages 631 - 640
AM. J. PATHOL., vol. 164, no. 2, February 2004 (2004-02-01), pages 449 - 456
TRENDS CARDIOVASC. MED., vol. 14, no. 5, July 2004 (2004-07-01), pages 196 - 202
J. HEPATOL., vol. 31, no. 4, October 1999 (1999-10-01), pages 703 - 711
J. LAB. CLIN. MED., vol. 144, no. 2, August 2004 (2004-08-01), pages 69 - 77
ONCOGENE, vol. 22, no. 28, 10 July 2003 (2003-07-10), pages 4389 - 4397
AM. J. PATHOL., vol. 172, no. 3, March 2008 (2008-03-01), pages 691 - 701
JACOBSEN JS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 105, no. 25, 2008, pages 8754 - 8759
Attorney, Agent or Firm:
Saegusa & Partners et al. (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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