Title:
RORγT INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/139595
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicines, in particular to a RORγt inhibitor as well as a preparation method therefor and uses thereof, and also relates to a pharmaceutical composition comprising the compound, a method for preparing the pharmaceutical composition, and use of the compound or the pharmaceutical composition in the treatment or prevention of RORγt-mediated cancer, inflammation, or autoimmune diseases in mammals, especially in humans.
Inventors:
LIU BING (CN)
ZHANG YINGJUN (CN)
PAN WEI (CN)
WANG FENG (CN)
LI XUKE (CN)
HE WEI (CN)
HUANG JIUZHONG (CN)
ZHANG YINGJUN (CN)
PAN WEI (CN)
WANG FENG (CN)
LI XUKE (CN)
HE WEI (CN)
HUANG JIUZHONG (CN)
Application Number:
PCT/CN2020/141903
Publication Date:
July 15, 2021
Filing Date:
December 31, 2020
Export Citation:
Assignee:
DONGGUAN HEC NEW DRUG R&D CO LTD (CN)
SUNSHINE LAKE PHARMA CO LTD (CN)
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D295/155; A61K31/5375; A61K31/5377; A61P19/02; A61P35/00; C07D413/04; C07D417/04
Domestic Patent References:
| WO2020011147A1 | 2020-01-16 | |||
| WO2018116285A1 | 2018-06-28 | |||
| WO2017010399A1 | 2017-01-19 | |||
| WO2018185675A1 | 2018-10-11 | |||
| WO2016193452A1 | 2016-12-08 | |||
| WO2017087608A1 | 2017-05-26 | |||
| WO2019088057A1 | 2019-05-09 | |||
| WO2019213470A1 | 2019-11-07 |
Foreign References:
| CN105980353A | 2016-09-28 | |||
| US4328245A | 1982-05-04 | |||
| US4409239A | 1983-10-11 | |||
| US4410545A | 1983-10-18 | |||
| US6350458B1 | 2002-02-26 |
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JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
ROBERT E. GAWLEYJEFFREY AUBE: "Principles of Asymmetric Synthesis", 2012, ELSEVIER
ELIEL, E.L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
"Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
T. HIGUCHIV STELLA: "Bioreversible Carriers in Drug Design", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS, article "Pro-drugs as Novel Delivery Systems"
J. RAUTIO ET AL., PRODRUGS: DESIGN AND CLINICAL APPLICATIONS, NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270
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S. M. BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
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STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
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"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
REMINGTON: "The Science and Practice of Pharmacy"
EBERL ET AL., NAT IMMUNOL., vol. 5, 2004, pages 64 - 73
IVANOV, IIMCKENZIE BSZHOU LTADOKORO CELEPELLEY ALAFAILLE JJ ET AL., CELL, vol. 126, no. 6, 2006, pages 1121 - 33
JETTEN ET AL., NUCL. RECEPT. SIGNAL, vol. 7, 2009, pages e003
MANEL ET AL., NAT. IMMUNOL., vol. 9, 2008, pages 641 - 649
KORN ET AL., ANNU. REV. IMMUNOL., vol. 27, 2009, pages 485 - 517
JETTEN ET AL., ADV. DEV.BIOL, vol. 16, 2006, pages 313 - 355
MEIER ET AL., IMMUNITY, vol. 26, 2007, pages 643 - 654
ALOISI ET AL., NAT. REV. IMMUNOL., vol. 6, 2006, pages 205 - 217
JAGER ET AL., J. IMMUNOL., vol. 183, 2009, pages 7169 - 7177
BARNES ET AL., NAT. REV. IMMUNOL., vol. 8, 2008, pages 183 - 192
ELIEL, E.WILEN, S.: "Periodic Table of the Elements, CAS version, and the Handbook of Chemistry and Physics", 1994, JOHN WILEY & SONS
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "Chiral Separation Techniques: A Practical Approach", 2007, WILEY-VCH VERLAG GMBH & CO.
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
ROBERT E. GAWLEYJEFFREY AUBE: "Principles of Asymmetric Synthesis", 2012, ELSEVIER
ELIEL, E.L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
"Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
T. HIGUCHIV STELLA: "Bioreversible Carriers in Drug Design", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS, article "Pro-drugs as Novel Delivery Systems"
J. RAUTIO ET AL., PRODRUGS: DESIGN AND CLINICAL APPLICATIONS, NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270
S. J. HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
S. M. BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY, pages: 1289 - 1329
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
"Remington: The Science and Practice of Pharmacy", 2005, AMERICAN PHARMACEUTICAL ASSOCIATION AND THE PHARMACEUTICAL PRESS
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
REMINGTON: "The Science and Practice of Pharmacy"
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