Title:
INHIBITOR OF UBIQUITIN-SPECIFIC PROTEASE 1 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/094170
Kind Code:
A1
Abstract:
Disclosed are an inhibitor compound of ubiquitin-specific protease 1 and a use thereof. The inhibitor compound specifically relates to a compound represented by formula (I) or an enantiomer, a diastereomer, a racemate, a tautomer, a stereoisomer, a geometric isomer, a nitrogen oxide, a metabolite or a pharmaceutically acceptable salt thereof, an ester, a solvate, a hydrate, an isotope-labeled compound (preferably a deuterated substance) or a prodrug of the compound.
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Inventors:
DENG XINYUAN (CN)
QIAO DONGMING (CN)
XUE SIJING (CN)
CHEN DAOXING (CN)
BAI LU (CN)
WANG SHAOHUI (CN)
CHEN BIN (CN)
ZHANG PEIYU (CN)
QIAO DONGMING (CN)
XUE SIJING (CN)
CHEN DAOXING (CN)
BAI LU (CN)
WANG SHAOHUI (CN)
CHEN BIN (CN)
ZHANG PEIYU (CN)
Application Number:
PCT/CN2023/129590
Publication Date:
May 10, 2024
Filing Date:
November 03, 2023
Export Citation:
Assignee:
SHENZHEN JINGTAI TECH CO LTD (CN)
International Classes:
C07D403/14; A61K31/506; A61P35/00; C07D401/14; C07D403/12; C07D487/04
Domestic Patent References:
| WO2014105952A2 | 2014-07-03 | |||
| WO2022214053A1 | 2022-10-13 | |||
| WO2022228399A1 | 2022-11-03 |
Foreign References:
| CN116496252A | 2023-07-28 | |||
| CN103649074A | 2014-03-19 | |||
| CN113164485A | 2021-07-23 |
Other References:
DEXHEIMER, THOMAS S. ET AL.: "Synthesis and Structure-Activity Relationship Studies of N-Benzyl-2-phenylpyrimidin-4-amine Derivatives as Potent USP 1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity against Nonsmall Cell Lung Cancer", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, 17 September 2014 (2014-09-17), pages 8099 - 8110, XP055330334, DOI: 10.1021/jm5010495
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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