INHIBITORS OF BACE - VERTEX PHARMA

Title:

INHIBITORS OF BACE

Document Type and Number:

WIPO Patent Application WO2002088101

Kind Code:

A3

Abstract:

The present invention relates to inhibitors of aspartic proteinases, particularly, BACE. The present invention also relates to compositions thereof and methods therewith for inhibiting BACE activity in a mammal, and for treating Alzheimer's Disease and other BACE-mediated diseases.

Inventors:

BHISETTI GOVINDA R (US)
SAUNDERS JEFFREY O (US)
MURCKO MARK A (US)
LEPRE CHRISTOPHER A (US)
BRITT SHAWN D (US)
COME JON H (US)
DENINGER DAVID D (US)
WANG TIANSHANG (US)

Application Number:

PCT/US2002/013741

Publication Date:

January 03, 2003

Filing Date:

April 29, 2002

Export Citation:

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Assignee:

VERTEX PHARMA (US)
BHISETTI GOVINDA R (US)
SAUNDERS JEFFREY O (US)
MURCKO MARK A (US)
LEPRE CHRISTOPHER A (US)
BRITT SHAWN D (US)
COME JON H (US)
DENINGER DAVID D (US)
WANG TIANSHANG (US)

International Classes:

A61K31/4409; A61K31/4439; A61K31/444; A61K31/47; A61K31/495; A61K31/496; A61K31/506; A61K31/55; A61K31/551; A61P25/28; C07D211/70; C07D211/72; C07D211/74; C07D211/82; C07D213/75; C07D217/26; C07D239/48; C07D241/04; C07D243/08; C07D295/12; C07D295/135; C07D401/04; C07D401/10; C07D401/12; C07D403/04; C07D405/10; C07D405/14; C07D487/04; (IPC1-7): C07D295/12; C07D215/48; C07D241/04; C07D239/48; C07D211/74; C07D211/82; C07D401/12; C07D405/14; C07D487/04; A61K31/55; A61P25/28

Domestic Patent References:

WO1998027081A1	1998-06-25
WO1997038989A1	1997-10-23
WO1999033793A2	1999-07-08
WO2001052845A1	2001-07-26

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