Title:
INHIBITORS OF CHECKPOINT KINASES
Document Type and Number:
WIPO Patent Application WO/2006/074207
Kind Code:
A3
Abstract:
The instant invention provides for compounds which comprise fused pyrazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
Inventors:
BRNARDIC EDWARD J (US)
FRALEY MARK E (US)
GARBACCIO ROBERT M (US)
FRALEY MARK E (US)
GARBACCIO ROBERT M (US)
Application Number:
PCT/US2006/000152
Publication Date:
September 23, 2010
Filing Date:
January 05, 2006
Export Citation:
Assignee:
MERCK & CO INC (US)
BRNARDIC EDWARD J (US)
FRALEY MARK E (US)
GARBACCIO ROBERT M (US)
BRNARDIC EDWARD J (US)
FRALEY MARK E (US)
GARBACCIO ROBERT M (US)
International Classes:
A61K31/44
Domestic Patent References:
| WO2001027116A2 | 2001-04-19 | |||
| WO2003086404A1 | 2003-10-23 | |||
| WO2006074207A2 | 2006-07-13 |
Other References:
KERRY ET AL.: "The synthesis of benzo[h]quinolines as topoisomerase inhibitors", J CHEM SOC. PERKIN TRANS, vol. 1, 1999, pages 2315 - 2321
Attorney, Agent or Firm:
MERCK & CO., INC. (Rahway, New Jersey, US)
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