INHIBITORS OF DDR1 AND DDR2 FOR THE TREATMENT OF ARTHRITIS

Title:

INHIBITORS OF DDR1 AND DDR2 FOR THE TREATMENT OF ARTHRITIS

Document Type and Number:

WIPO Patent Application WO/2023/196714

Kind Code:

A3

Abstract:

Provided herein are compounds, such as compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are DDR1, DDR2, or p38 MAPK (e.g., p38-alpha) inhibitors and are therefore useful for the treatment and/or prevention of various diseases and conditions (e.g., inflammatory diseases, joint diseases, proliferative diseases, fibrosis, or pain).

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Inventors:

LI YEFU (US)
XU LIN (US)

Application Number:

PCT/US2023/063009

Publication Date:

April 11, 2024

Filing Date:

February 22, 2023

Export Citation:

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Assignee:

HARVARD COLLEGE (US)

International Classes:

C07D239/48; A61K31/18; A61K31/505; C07C309/29

Attorney, Agent or Firm:

LIDSTON, Claire, A. L. et al. (US)

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