Title:
INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE
Document Type and Number:
WIPO Patent Application WO/2019/140188
Kind Code:
A1
Abstract:
Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic disorders, where inhibition of Des1 is expected to be therapeutic to a patient. Methods of inhibition of Des1 activity in a human or animal subject are also provided.
Inventors:
ROMERO DONNA (US)
BLITZER JEREMY (US)
BLITZER JEREMY (US)
Application Number:
PCT/US2019/013193
Publication Date:
July 18, 2019
Filing Date:
January 11, 2019
Export Citation:
Assignee:
CENTAURUS THERAPEUTICS (US)
International Classes:
A61K31/165; C07C233/29; C07C235/38
Domestic Patent References:
| WO1999021585A1 | 1999-05-06 | |||
| WO2002050018A1 | 2002-06-27 | |||
| WO2018112077A1 | 2018-06-21 |
Foreign References:
| US20110124730A1 | 2011-05-26 | |||
| US6375957B1 | 2002-04-23 |
Other References:
ZHENG, FENRETINIDE INCREASES DIHYDROCERAMIDE AND DIHYDROSPHINGOLIPIDS DUE TO INHIBITION OF DIHYDROCERAMIDE DESATURASE (THESIS), 1 August 2006 (2006-08-01), pages 1 - 44, XP055624558, Retrieved from the Internet [retrieved on 20190308]
DATABASE Pubmed U.S. National Library of Medicine; 26 March 2005 (2005-03-26), "N-Phenylbenzenesulfonamide", XP055624559, Database accession no. 74296
See also references of EP 3737361A4
DATABASE Pubmed U.S. National Library of Medicine; 26 March 2005 (2005-03-26), "N-Phenylbenzenesulfonamide", XP055624559, Database accession no. 74296
See also references of EP 3737361A4
Attorney, Agent or Firm:
BENNETT, Dennis (US)
Download PDF:
Previous Patent: MOUNTING SYSTEMS FOR SOLAR PHOTOVOLTAIC (PV) POWER PLANTS
Next Patent: AFFINE MOTION COMPENSATION WITH LOW BANDWIDTH
Next Patent: AFFINE MOTION COMPENSATION WITH LOW BANDWIDTH