Title:
INHIBITORS OF HB-EGF (ERBB) RECEPTORS FOR TREATING MYELOMA
Document Type and Number:
WIPO Patent Application WO/2003/013485
Kind Code:
A1
Abstract:
The invention concerns the use of at least an inhibitor of the heparin-binding epidermal growth factor or at least an inhibitor of the HB-EGF receptors, or ErbB receptors, or of at least an inhibitor of associated transduction pathways for preparing medicines useful for treating apoptosis and/or inhibiting IL-6 dependent plasmocytic tumor cell proliferation.
Inventors:
KLEIN BERNARD (FR)
DE VOS JOHN (FR)
WANG YUE DAN (CN)
DE VOS JOHN (FR)
WANG YUE DAN (CN)
Application Number:
PCT/FR2002/002777
Publication Date:
February 20, 2003
Filing Date:
August 01, 2002
Export Citation:
Assignee:
CHU MONTPELLIER (FR)
CELLGEN SARL (FR)
KLEIN BERNARD (FR)
DE VOS JOHN (FR)
WANG YUE DAN (CN)
CELLGEN SARL (FR)
KLEIN BERNARD (FR)
DE VOS JOHN (FR)
WANG YUE DAN (CN)
International Classes:
A61K45/00; A61K31/00; A61K31/56; A61K31/727; A61K38/00; A61K38/17; A61K38/20; A61K39/395; A61P5/00; A61P35/00; A61P43/00; C07K16/22; C07K16/28; (IPC1-7): A61K31/00; A61K31/727; A61K39/05; A61K39/395; A61K45/06
Domestic Patent References:
| WO1999007407A1 | 1999-02-18 |
Foreign References:
| US6090794A | 2000-07-18 | |||
| US4757056A | 1988-07-12 | |||
| US5366874A | 1994-11-22 | |||
| US6235884B1 | 2001-05-22 | |||
| US6172042B1 | 2001-01-09 |
Other References:
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; XP002199053, retrieved from EPOQUE BIOSIS Database accession no. prev200100312143
RAAB G ET AL: "HEPARIN-BINDING EGF-LIKE GROWTH FACTOR", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 1333, no. 3, 1997, pages E179 - E199, XP000961069, ISSN: 0006-3002
CHADWICK D.E. ET AL: "Differential sensitivity of human myeloma cell lines and normal bone marrow colony forming cell to a recombinant diphtheria toxin- interleukin 6 fusion protein.", BRITISH JOURNAL OF HAEMATOLOGY, (1993) 85/1 (25-36)., XP008002427
IWAMOTO R ET AL: "HEPARIN-BINDING EGF-LIKE GROWTH FACTOR, WHICH ACTS ARE THE DIPHTHERIA TOXIN RECEPTOR, FORMS A COMPLEX WITH MEMBRANE PROTEIN DRAP27/CD9, WHICH UP-REGULATES FUNCTIONAL RECEPTORS AND DIPHTHERIA TOXIN SENSITIVITY", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 10, no. 13, 1994, pages 2322 - 2330, XP001064892, ISSN: 0261-4189
SHALLAL ET AL.: "CD9 expression enhances the susceptibility of myeloma cell lines to cell-mediated cytolysis", BLOOD, vol. 96, no. 1, July 2000 (2000-07-01), pages 224 - 233, XP002199051
MITAMURA T ET AL: "DIPHTHERIA TOXIN BINDS TO THE EPIDERMAL GROWTH FACTOR (EGF)-LIKE DOMAIN OF HUMAN HEPARIN-BINDING EGF-LIKE GROWTH FACTOR/DIPHTHERIA TOXIN RECEPTOR AND INHIBITS SPECIFICALLY ITS MITOGENIC ACTIVITY", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 270, no. 3, 20 January 1995 (1995-01-20), pages 1015 - 1019, XP002912324, ISSN: 0021-9258
BESNER ET AL.: "Interaction of heparin-binding EGF-like growth factor (HB-EGF) with the epidermal growth factor receptor: modulation by heparin, heparinase, or synthetic heparin-binding HB-EGF fragments", GROWTH FACTROS, vol. 7, 1992, pages 289 - 296, XP008003012
KAWANO ET AL.: "Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas", NATURE, vol. 332, 3 March 1988 (1988-03-03), pages 83 - 85, XP002199052
DATABASE MEDLINE [online] XP002199054, retrieved from EPOQUE MEDLINE Database accession no. NLM8977259
DATABASE MEDLINE [online] XP002199055, retrieved from EPOQUE MEDLINE Database accession no. NLM2592570
DATABASE MEDLINE [online] XP002199056, retrieved from EPOQUE MEDLINE Database accession no. NLM7989587
RUIZ-ARGUËLLES ET AL.: "Cell surface markers in multiple myeloma", MAYO CLINIC PROC., vol. 69, no. 7, July 1994 (1994-07-01), pages 684 - 690, XP008002967
DATABASE MEDLINE [online] XP002199057, retrieved from EPOQUE MEDLINE Database accession no. NLM 8603522
VINANTE F ET AL: "HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR/DIPHTHERIA TOXIN RECEPTOR EXPRESSION BY ACUTE MYELOID LEUKEMIA CELLS", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 5, no. 93, 1 March 1999 (1999-03-01), pages 1715 - 1723, XP001066282, ISSN: 0006-4971
DE VOS ET AL.: "Identifying intercelullar signaling genes expressed in malignant plasma cells by using complementary DNA arrays", BLOOD, vol. 98, no. 3, 1 August 2001 (2001-08-01), pages 771 - 778, XP001076688
DE VOS ET AL.: "Comparing myeloma cells to normal plasma cells by using oligonucleotides microarrays: toward new therapeutic targets", BLOOD, vol. 98, no. 11-1, 16 November 2001 (2001-11-16), pages 570a, XP001068208
See also references of EP 1411907A1
RAAB G ET AL: "HEPARIN-BINDING EGF-LIKE GROWTH FACTOR", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 1333, no. 3, 1997, pages E179 - E199, XP000961069, ISSN: 0006-3002
CHADWICK D.E. ET AL: "Differential sensitivity of human myeloma cell lines and normal bone marrow colony forming cell to a recombinant diphtheria toxin- interleukin 6 fusion protein.", BRITISH JOURNAL OF HAEMATOLOGY, (1993) 85/1 (25-36)., XP008002427
IWAMOTO R ET AL: "HEPARIN-BINDING EGF-LIKE GROWTH FACTOR, WHICH ACTS ARE THE DIPHTHERIA TOXIN RECEPTOR, FORMS A COMPLEX WITH MEMBRANE PROTEIN DRAP27/CD9, WHICH UP-REGULATES FUNCTIONAL RECEPTORS AND DIPHTHERIA TOXIN SENSITIVITY", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 10, no. 13, 1994, pages 2322 - 2330, XP001064892, ISSN: 0261-4189
SHALLAL ET AL.: "CD9 expression enhances the susceptibility of myeloma cell lines to cell-mediated cytolysis", BLOOD, vol. 96, no. 1, July 2000 (2000-07-01), pages 224 - 233, XP002199051
MITAMURA T ET AL: "DIPHTHERIA TOXIN BINDS TO THE EPIDERMAL GROWTH FACTOR (EGF)-LIKE DOMAIN OF HUMAN HEPARIN-BINDING EGF-LIKE GROWTH FACTOR/DIPHTHERIA TOXIN RECEPTOR AND INHIBITS SPECIFICALLY ITS MITOGENIC ACTIVITY", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 270, no. 3, 20 January 1995 (1995-01-20), pages 1015 - 1019, XP002912324, ISSN: 0021-9258
BESNER ET AL.: "Interaction of heparin-binding EGF-like growth factor (HB-EGF) with the epidermal growth factor receptor: modulation by heparin, heparinase, or synthetic heparin-binding HB-EGF fragments", GROWTH FACTROS, vol. 7, 1992, pages 289 - 296, XP008003012
KAWANO ET AL.: "Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas", NATURE, vol. 332, 3 March 1988 (1988-03-03), pages 83 - 85, XP002199052
DATABASE MEDLINE [online] XP002199054, retrieved from EPOQUE MEDLINE Database accession no. NLM8977259
DATABASE MEDLINE [online] XP002199055, retrieved from EPOQUE MEDLINE Database accession no. NLM2592570
DATABASE MEDLINE [online] XP002199056, retrieved from EPOQUE MEDLINE Database accession no. NLM7989587
RUIZ-ARGUËLLES ET AL.: "Cell surface markers in multiple myeloma", MAYO CLINIC PROC., vol. 69, no. 7, July 1994 (1994-07-01), pages 684 - 690, XP008002967
DATABASE MEDLINE [online] XP002199057, retrieved from EPOQUE MEDLINE Database accession no. NLM 8603522
VINANTE F ET AL: "HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR/DIPHTHERIA TOXIN RECEPTOR EXPRESSION BY ACUTE MYELOID LEUKEMIA CELLS", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 5, no. 93, 1 March 1999 (1999-03-01), pages 1715 - 1723, XP001066282, ISSN: 0006-4971
DE VOS ET AL.: "Identifying intercelullar signaling genes expressed in malignant plasma cells by using complementary DNA arrays", BLOOD, vol. 98, no. 3, 1 August 2001 (2001-08-01), pages 771 - 778, XP001076688
DE VOS ET AL.: "Comparing myeloma cells to normal plasma cells by using oligonucleotides microarrays: toward new therapeutic targets", BLOOD, vol. 98, no. 11-1, 16 November 2001 (2001-11-16), pages 570a, XP001068208
See also references of EP 1411907A1
Attorney, Agent or Firm:
Gillard, Marie-louise (158 Rue De L'Université, Paris Cedex 07, FR)
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