Title:
INHIBITORS OF HISTONE DEACETYLASE
Document Type and Number:
WIPO Patent Application WO2002046129
Kind Code:
A3
Abstract:
Compounds having the formula or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
Inventors:
CURTIN MICHAEL L
DAI YUJIA
DAVIDSEN STEVEN K
FREY ROBIN R
GUO YAN
HEYMAN HOWARD R
HOLMS JAMES H
JI ZHIQIN
MICHAELIDES MICHAEL R
VASUDEVAN ANIL
WADA CAROL K
DAI YUJIA
DAVIDSEN STEVEN K
FREY ROBIN R
GUO YAN
HEYMAN HOWARD R
HOLMS JAMES H
JI ZHIQIN
MICHAELIDES MICHAEL R
VASUDEVAN ANIL
WADA CAROL K
Application Number:
PCT/US2001/050931
Publication Date:
January 16, 2003
Filing Date:
October 26, 2001
Export Citation:
Assignee:
ABBOTT LAB (US)
International Classes:
C07C45/29; C07C45/30; C07C45/45; C07C45/51; C07C45/67; C07C47/277; C07C49/255; C07C59/90; C07C69/716; C07C235/14; C07C235/16; C07C235/20; C07C235/74; C07C235/80; C07C243/38; C07C255/54; C07C255/60; C07C311/19; C07C317/32; C07C317/44; C07C323/41; C07C323/60; C07D209/08; C07D209/42; C07D213/30; C07D213/40; C07D213/75; C07D215/38; C07D231/40; C07D235/06; C07D257/04; C07D263/14; C07D263/32; C07D263/58; C07D271/10; C07D277/46; C07D277/56; C07D277/74; C07D277/82; C07D285/08; C07D295/112; C07D307/68; C07D307/85; C07D317/58; C07D317/66; C07D317/68; C07D413/04; C07D413/12; C07D417/04; C07D491/10; (IPC1-7): C07C235/14; C07C235/16; C07C235/20; C07C235/74; C07C235/80; C07C243/38; C07C255/54; C07C255/60; C07D295/10
Other References:
MANFRED JUNG ET AL: "Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 22, 4 November 1999 (1999-11-04), pages 4669 - 4679, XP002144226, ISSN: 0022-2623
SUZUKI ET AL: "Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 15, 1999, pages 3001 - 3003, XP002158227, ISSN: 0022-2623
SUZUKI ET AL: "Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 15, 1999, pages 3001 - 3003, XP002158227, ISSN: 0022-2623
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