PI3Kα INHIBITORS AND METHODS OF USE THEREOF

Title:

PI3Kα INHIBITORS AND METHODS OF USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/220131

Kind Code:

A3

Abstract:

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Kα signaling with the compounds and compositions of the disclosure.

Inventors:

PAN YUE (US)
BOEZIO ALESSANDRO (US)
FRIDRICH CARY GRIFFIN (US)
KRUEGER ELAINE B (US)
MOUSTAKAS DEMETRI T (US)
RAYNOR KEVIN DAVID (US)
SHORTSLEEVES KELLEY C (US)
MCLEAN THOMAS H (US)
DENINNO MICHAEL PAUL (US)
THOMSON CHRISTOPHER (GB)
LARIVEE ALEXANDRE (CA)
BURNIE ANDREW J (CA)
ATIENZA BREN-JORDAN (CA)
PERREAULT CHRISTIAN (CA)
MAERTENS GAETAN (CA)
MOHAMED TAREK (CA)
LEPITRE THOMAS (CA)
BAUM ERICH W (US)
GUNAYDIN HAKAN (US)

Application Number:

PCT/US2023/021668

Publication Date:

January 04, 2024

Filing Date:

May 10, 2023

Export Citation:

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Assignee:

RELAY THERAPEUTICS INC (US)

International Classes:

C07C25/02; A61K31/03; A61P35/00

Domestic Patent References:

WO2020231990A1

2020-11-19

Foreign References:

US9926324B2	2018-03-27
US20070010548A1	2007-01-11
US8614215B2	2013-12-24

Other References:

DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "101-81-5", XP093126735, retrieved from PUBCHEM

Attorney, Agent or Firm:

REID, Andrea L.C. et al. (US)

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