Title:
INHIBITORS OF PHOSPHODIESTERASE TYPE-IV
Document Type and Number:
WIPO Patent Application WO2005021515
Kind Code:
B1
Abstract:
The present invention relates to isoxazoline derivatives of structure (I), which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors. Formula I.
Inventors:
PALLE VENKATA P (IN)
BALACHANDRAN SARALA (IN)
SALMAN MOHAMMAD (IN)
KUKREJA GAGAN (IN)
GUPTA NIDHI (IN)
RAY ABHIJIT (IN)
DASTIDAR SUNANDA G (IN)
BALACHANDRAN SARALA (IN)
SALMAN MOHAMMAD (IN)
KUKREJA GAGAN (IN)
GUPTA NIDHI (IN)
RAY ABHIJIT (IN)
DASTIDAR SUNANDA G (IN)
Application Number:
PCT/IB2004/002804
Publication Date:
October 27, 2005
Filing Date:
August 30, 2004
Export Citation:
Assignee:
RANBAXY LAB LTD (IN)
PALLE VENKATA P (IN)
BALACHANDRAN SARALA (IN)
SALMAN MOHAMMAD (IN)
KUKREJA GAGAN (IN)
GUPTA NIDHI (IN)
RAY ABHIJIT (IN)
DASTIDAR SUNANDA G (IN)
PALLE VENKATA P (IN)
BALACHANDRAN SARALA (IN)
SALMAN MOHAMMAD (IN)
KUKREJA GAGAN (IN)
GUPTA NIDHI (IN)
RAY ABHIJIT (IN)
DASTIDAR SUNANDA G (IN)
International Classes:
A61K31/42; A61K31/422; A61K31/423; A61K31/424; C07C45/61; C07C269/06; C07D261/02; C07D261/04; C07D261/20; C07D413/06; C07D413/14; C07D487/08; C07D491/02; C07D498/10; (IPC1-7): C07D261/04; A61K31/422; A61K31/423; A61K31/424; C07C45/61; C07C269/06; C07D261/20; C07D413/06; C07D413/14; C07D487/08; C07D498/10
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