INHIBITORS OF SARM1

WIPO Patent Application WO/2020/252229

A3

The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

WO/2009/155659	COMBINATION THERAPY
JPH072634	[Title of Invention] An antitumor agent containing an acetic acid derivative
JPH0780760	INDUSTRIAL APPLICABILITY: Stabilized phenylefrine-based liquid agent

HUGHES ROBERT OWEN (US)
DEVRAJ RAJESH (US)
BOSANAC TODD (US)
JARJES-PIKE RICHARD ANDREW (GB)
BREARLEY ANDREW SIMON (GB)
BENTLEY JONATHAN (GB)
PARROTT SHELLEY ANNE (GB)
COOPER SOPHIE CATHERINE (GB)

PCT/US2020/037378

January 21, 2021

June 12, 2020

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DISARM THERAPEUTICS INC (US)

A61K31/19; A61K31/455; A61K31/4745

EP1050531A1	2000-11-08
US20150011575A1	2015-01-08

GERDTS JOSIAH; SUMMERS DANIEL W.; MILBRANDT JEFFREY; DIANTONIO AARON: "Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism", NEURON, CELL PRESS, US, vol. 89, no. 3, 3 February 2016 (2016-02-03), US, pages 449 - 460, XP029406975, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2015.12.023
LAWRENCE HARSHANI R., MARTIN MATHEW P., LUO YUNTING, PIREDDU ROBERTA, YANG HUA, GEVARIYA HARSUKH, OZCAN SEVIL, ZHU JIN-YI, KENDIG : "Development of o -Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 55, no. 17, 13 September 2012 (2012-09-13), US, pages 7392 - 7416, XP055783726, ISSN: 0022-2623, DOI: 10.1021/jm300334d

BUTEAU, Kristen C. et al. (US)

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