Title:
INHIBITORS OF ZIKA VIRUS INFECTION
Document Type and Number:
WIPO Patent Application WO/2021/035068
Kind Code:
A3
Abstract:
The present specification provides methods of treatment of flavivirus infection, such as Zika or dengue virus infection, by administration of gossypol, a gossypol derivative, digitonin, or conessine. These compounds may be used alone, in combination with each other, or in combination with curcumin or bortezomib.
Inventors:
DU LANYING (US)
DEBNATH ASIM KUMAR (US)
JIANG SHIBO (US)
GAO YANING (US)
DEBNATH ASIM KUMAR (US)
JIANG SHIBO (US)
GAO YANING (US)
Application Number:
PCT/US2020/047233
Publication Date:
April 08, 2021
Filing Date:
August 20, 2020
Export Citation:
Assignee:
NEW YORK BLOOD CENTER INC (US)
International Classes:
C12N7/00; A61P31/12; A61P31/14
Foreign References:
| US20080161324A1 | 2008-07-03 |
Other References:
QAMAR ET AL.: "Computer Aided Screening of Phytochemicals from Garcinia against the Dengue NS2B/NS3 Protease", BIOINFORMATION, vol. 10, no. 3, 19 March 2014 (2014-03-19), pages 115 - 118, XP055811341
GAO ET AL.: "Identification of Novel Natural Products as Effective and Broad-Spectrum Anti-Zika Virus Inhibitors", VIRUSES, vol. 11, no. 11, 2 November 2019 (2019-11-02), pages 1019, XP055811345
GAO ET AL.: "Identification of Novel Natural Products as Effective and Broad-Spectrum Anti-Zika Virus Inhibitors", VIRUSES, vol. 11, no. 11, 2 November 2019 (2019-11-02), pages 1019, XP055811345
Attorney, Agent or Firm:
CULLMAN, Louis C. et al. (US)
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