Title:
INJECTABLE COMPOSITION FOR BONE REGENERATION
Document Type and Number:
WIPO Patent Application WO/2021/261954
Kind Code:
A1
Abstract:
The present invention relates to an injectable composition for bone regeneration, comprising 1cc of 6% (w/v) hydrated collagen, 5000 units of thrombin, 0.5 ml of a mixed solution of lidocaine and epinephrine in which the epinephrine amount is 1:100,000 (v/v) on the basis of lidocaine, and acting by being injected into bone marrow. The composition according to the present invention activates undifferentiated cells in bone marrow and also activates the bone regeneration ability in bone marrow through the activation and differentiation of osteoclasts and osteoblasts, and can be a successful treatment method for medication-related osteonecrosis of the jaws (MRONJ) through a myeloid activation treatment method, uses various growth factors for myeloid activation and myeloid activation factors such as cytokines so as to allow for the development of treatment for the fundamental cause of MRONJ through a myeloid activation treatment method, and enables the complete regeneration of jaw bone conditions with respect to aesthetic and function, and thus can be effectively used in the treatment of various diseases caused by bone remodeling failure.
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Inventors:
KWON KYUNG-HWAN (KR)
Application Number:
PCT/KR2021/008010
Publication Date:
December 30, 2021
Filing Date:
June 25, 2021
Export Citation:
Assignee:
DENHOUSE CO LTD (KR)
International Classes:
A61L27/54; A61C8/02; A61F2/28; A61K31/167; A61L27/24
Foreign References:
| KR20140090481A | 2014-07-17 | |||
| KR20190092059A | 2019-08-07 | |||
| KR20100007180A | 2010-01-22 | |||
| KR20130115781A | 2013-10-22 |
Other References:
SIVAGURUNATHAN S, PAGEL C N, LOH L H, WIJEYEWICKREMA L C, PIKE R N, MACKIE E J: "Thrombin inhibits osteoclast differentiation through a non-proteolytic mechanism", JOURNAL OF MOLECULAR ENDOCRINOLOGY, vol. 50, no. 3, 18 February 2013 (2013-02-18), pages 347 - 359, XP055882870, ISSN: 0952-5041, DOI: 10.1530/JME-12-0177
Attorney, Agent or Firm:
JUNG, Yeo Soon et al. (KR)
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