Title:
INJECTABLE HYALURONIC ACID MICROSPHERE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/197419
Kind Code:
A1
Abstract:
An injectable hyaluronic acid microsphere, a preparation method therefor and use thereof. The method comprises: adding cross-linked hyaluronic acid into an aqueous solvent to prepare a first liquid phase, the concentration of the cross-linked hyaluronic acid in the first liquid phase being controlled at 0.1-5 wt%; adding an internal polyester into an organic solvent to prepare a second liquid phase, the concentration of the internal polyester in the second liquid phase being controlled at 0.1-500 mg/mL; and then mixing the first liquid phase with the second liquid phase in a volume ratio of 3-15:1 to prepare the microsphere. Under the same condition, the microsphere is not prone to aggregation and adhesion, and has higher cell adhesion and histocompatibility.
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Inventors:
GUO JIANJUN (CN)
SONG CHUNYAN (CN)
LV JINYAN (CN)
YU LIUSONG (CN)
SITU WEI (CN)
SONG CHUNYAN (CN)
LV JINYAN (CN)
YU LIUSONG (CN)
SITU WEI (CN)
Application Number:
PCT/CN2022/095715
Publication Date:
October 19, 2023
Filing Date:
May 27, 2022
Export Citation:
Assignee:
ZHUHAI MAIDEFA BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61L27/26; A61L27/50
Domestic Patent References:
| WO2002009787A1 | 2002-02-07 | |||
| WO2020002597A1 | 2020-01-02 |
Foreign References:
| CN113616604A | 2021-11-09 | |||
| CN101244290A | 2008-08-20 | |||
| CN113617305A | 2021-11-09 | |||
| CN113230451A | 2021-08-10 | |||
| CN113730652A | 2021-12-03 |
Attorney, Agent or Firm:
GUANGZHOU PRIME IP LAW OFFICE (CN)
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