INJECTABLE HYDROGEL ADHESIVE HAVING BOTH FAST-CURING AND ANTI-SWELLING PROPERTIES AND USE

WIPO Patent Application WO/2024/026668

A9

Disclosed in the present invention are an injectable hydrogel adhesive having both fast-curing and anti-swelling properties and a use. The injectable hydrogel adhesive comprises the following components in percentage by mass: 5%-20% of terminal-biodegradable poloxamer, 0.1%-5% of small adhesion molecules, 0.1%-0.5% of photoinitiator, and a dissolving amount of solving liquid, wherein the terminal-biodegradable poloxamer is obtained by introducing a terminal modification structure to two terminals of poloxamer, the terminal modification structure has a molecular weight of less than 300 and contains a biodegradable ester bond or amide bond, and a carbon-carbon double bond is at the endmost position of the terminal modification structure. The injectable hydrogel adhesive has both fast adhesion and anti-swelling properties, can achieve adhesion of wet tissue within several seconds after ultraviolet irradiation, can be used for wound closure and rapid hemostasis, and is particularly suitable for wound treatment in neurosurgery, thereby avoiding the risk of compression of nervous tissue due to volume expansion of adhesives after surgery, and guaranteeing the postoperative safety of patients.

ZHAO XIAOLI (CN)
BIAN SHAOQUAN (CN)
PAN HAOBO (CN)

PCT/CN2022/109659

March 14, 2024

August 02, 2022

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SHENZHEN INST ADV TECH (CN)

C08G65/337; A61L24/00; A61L24/04; A61L24/08; A61L24/10; A61L26/00; C08F220/06; C08F290/06; C08G65/332; C08G65/333

BEIJING CHENGHUI LAW FIRM (CN)

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