Title:
INJECTABLE HYDROGEL HAVING ANTI-INFLAMMATORY AND REPAIR-PROMOTING FUNCTION, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN HEART REPAIR
Document Type and Number:
WIPO Patent Application WO/2021/223756
Kind Code:
A1
Abstract:
Disclosed are a hydrogel having an anti-inflammatory and repair-promoting function, a preparation method therefor and an application thereof. The injectable hydrogel forms a gel by means of interaction between a functional group of a polymer and an o-hydroxyl group of the polymer, and in response to acidic conditions and/or active oxygen conditions, the hydrogel disintegrates after the interaction between the functional group of the polymer and the o-hydroxyl group of the polymer is released. The preparation method comprises: preparing a first polymer containing a functional group; and mixing one or more of an extracellular matrix, hydrophilic drugs or hydrophobic drugs, the first polymer, and an o-hydroxyl containing polymer to prepare the injectable hydrogel.
Inventors:
WANG YUNBING (CN)
HU CHENG (CN)
YANG LI (CN)
LIU WENQI (CN)
SHAO NAN (CN)
HU CHENG (CN)
YANG LI (CN)
LIU WENQI (CN)
SHAO NAN (CN)
Application Number:
PCT/CN2021/092474
Publication Date:
November 11, 2021
Filing Date:
May 08, 2021
Export Citation:
Assignee:
UNIV SICHUAN (CN)
International Classes:
A61L26/00
Domestic Patent References:
| WO2019053269A1 | 2019-03-21 | |||
| WO2008039827A2 | 2008-04-03 |
Foreign References:
| CN111437438A | 2020-07-24 | |||
| CN101574514A | 2009-11-11 | |||
| CN101288779A | 2008-10-22 |
Other References:
HU CHENG; ZHANG FANJUN; LONG LINYU; KONG QUNSHOU; LUO RIFANG; WANG YUNBING: "Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 324, 7 May 2020 (2020-05-07), AMSTERDAM, NL , pages 204 - 217, XP086244554, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.05.010
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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