Title:
INJECTABLE HYDROGEL WHICH IS DEGRADATION-REGULATABLE AND HAS ELECTRICAL CONDUCTIVITY, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/010350
Kind Code:
A1
Abstract:
The present invention provides an injectable hydrogel and a preparation method therefor, the injectable hydrogel comprising a matrix monomer and reduced graphene oxide coated with a block copolymer, wherein the matrix monomer comprises a first monomer and a second monomer. The injectable hydrogel of the present invention can achieve, through degradation regulation, excellent stability and degradability as necessary, has excellent electrical conductivity, and spontaneously gels within a short time in a physiological environment without an initiator or an external stimulus, and thus can be injected with minimal invasiveness. Therefore, the injectable hydrogel of the present invention can be variously applied as a bioelectrode requiring long-term use, a tissue engineering conductive scaffold having biodegradable properties, or the like.
More Like This:
Inventors:
LEE JAE YOUNG (KR)
PARK JUNG GEON (KR)
PARK JUNG GEON (KR)
Application Number:
PCT/KR2023/009458
Publication Date:
January 11, 2024
Filing Date:
July 05, 2023
Export Citation:
Assignee:
GWANGJU INST SCIENCE & TECH (KR)
International Classes:
C08K9/08; A61K9/00; A61K9/06; A61L27/18; A61L27/26; C08J3/075; C08K3/04; C08L71/02
Foreign References:
| KR20130055847A | 2013-05-29 | |||
| KR20090057674A | 2009-06-08 |
Other References:
LI QIANG; LI FANGMEI; QI XIXI; WEI FUQIAO; CHEN HONGXIAO; WANG TING: "Pluronic® F127 stabilized reduced graphene oxide hydrogel for the treatment of psoriasis: In vitro and in vivo studies", COLLOIDS AND SURFACES B: BIOINTERFACES, ELSEVIER AMSTERDAM, NL, vol. 195, 7 July 2020 (2020-07-07), NL , XP086310522, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2020.111246
PRATHAMESH M. KHARKAR, MATTHEW S. REHMANN, KELSI M. SKEENS, EMANUAL MAVERAKIS, APRIL M. KLOXIN: "Thiol–ene Click Hydrogels for Therapeutic Delivery", HHS AUTHOR MANUSCRIPTS, NIH- NATIONAL LIBRARY OF MEDICINE, US, vol. 2, no. 2, 8 February 2016 (2016-02-08), US , pages 165 - 179, XP055611460, DOI: 10.1021/acsbiomaterials.5b00420
SHIN JISOO, CHO JUNG HO, CHO SEUNG-WOO: " Functional Hydrogel for the Application of Drug Delivery and Tissue Engineering", KOREAN INDUSTRIAL CHEMISTRY NEWS, vol. 18, no. 6, 1 January 2015 (2015-01-01), pages 1 - 11, XP093124656
YAN HUANG; HUAQIANG CAI; TING YU; XIULI SUN; BO TU; DONGYUAN ZHAO: "Highly Ordered Mesoporous Carbonaceous Frameworks from a Template of a Mixed Amphiphilic Triblock‐Copolymer System of PEO–PPO–PEO and Reverse PPO–PEO–PPO", CHEMISTRY - AN ASIAN JOURNAL, WILEY-VCH, HOBOKEN, USA, vol. 2, no. 10, 8 August 2007 (2007-08-08), Hoboken, USA, pages 1282 - 1289, XP072417217, ISSN: 1861-4728, DOI: 10.1002/asia.200700173
PARK JUNGGEON, LEE SANGHUN, LEE MINGYU, KIM HYUNG‐SEOK, LEE JAE YOUNG: "Injectable Conductive Hydrogels with Tunable Degradability as Novel Implantable Bioelectrodes", SMALL, WILEY, HOBOKEN, USA, vol. 19, no. 21, 1 May 2023 (2023-05-01), Hoboken, USA, pages 2300250, XP093124649, ISSN: 1613-6810, DOI: 10.1002/smll.202300250
PRATHAMESH M. KHARKAR, MATTHEW S. REHMANN, KELSI M. SKEENS, EMANUAL MAVERAKIS, APRIL M. KLOXIN: "Thiol–ene Click Hydrogels for Therapeutic Delivery", HHS AUTHOR MANUSCRIPTS, NIH- NATIONAL LIBRARY OF MEDICINE, US, vol. 2, no. 2, 8 February 2016 (2016-02-08), US , pages 165 - 179, XP055611460, DOI: 10.1021/acsbiomaterials.5b00420
SHIN JISOO, CHO JUNG HO, CHO SEUNG-WOO: " Functional Hydrogel for the Application of Drug Delivery and Tissue Engineering", KOREAN INDUSTRIAL CHEMISTRY NEWS, vol. 18, no. 6, 1 January 2015 (2015-01-01), pages 1 - 11, XP093124656
YAN HUANG; HUAQIANG CAI; TING YU; XIULI SUN; BO TU; DONGYUAN ZHAO: "Highly Ordered Mesoporous Carbonaceous Frameworks from a Template of a Mixed Amphiphilic Triblock‐Copolymer System of PEO–PPO–PEO and Reverse PPO–PEO–PPO", CHEMISTRY - AN ASIAN JOURNAL, WILEY-VCH, HOBOKEN, USA, vol. 2, no. 10, 8 August 2007 (2007-08-08), Hoboken, USA, pages 1282 - 1289, XP072417217, ISSN: 1861-4728, DOI: 10.1002/asia.200700173
PARK JUNGGEON, LEE SANGHUN, LEE MINGYU, KIM HYUNG‐SEOK, LEE JAE YOUNG: "Injectable Conductive Hydrogels with Tunable Degradability as Novel Implantable Bioelectrodes", SMALL, WILEY, HOBOKEN, USA, vol. 19, no. 21, 1 May 2023 (2023-05-01), Hoboken, USA, pages 2300250, XP093124649, ISSN: 1613-6810, DOI: 10.1002/smll.202300250
Attorney, Agent or Firm:
JIDAM IP LAW FIRM (KR)
Download PDF: