INJECTION CONTAINING STABLE MACROMOLECULAR I-TYPE RECOMBINANT COLLAGEN

Title:

INJECTION CONTAINING STABLE MACROMOLECULAR I-TYPE RECOMBINANT COLLAGEN

Document Type and Number:

WIPO Patent Application WO/2023/143394

Kind Code:

A1

Abstract:

The present invention relates to an injection containing stable macromolecular I-type recombinant collagen. The collagen injection contains macromolecular I-type recombinant collagen, injection water and excipients, wherein the macromolecular I-type recombinant collagen is composed of multiple repetitions of a short amino acid sequence (GAPGAPGSQGAPGLQ) from natural human I-type collagen as a repeating unit, and the number of repetitions is 75-110 times. The collagen injection of the present invention can be subjected to damp-heat sterilization under the condition that the macromolecular I-type recombinant collagen is not crosslinked using a cross-linking agent, so that the toxicity of a residue in a cross-linking agent in a collagen injection product to a human body can be effectively avoided.

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Inventors:

FAN DAIDI (CN)
WANG XIAOJUN (CN)
LUO PEIPEI (CN)
YAN JIANYA (CN)
LIU LIN (CN)

Application Number:

PCT/CN2023/073218

Publication Date:

August 03, 2023

Filing Date:

January 19, 2023

Export Citation:

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Assignee:

SHAANXI GIANT BIOTECHNOLOGY CO LTD (CN)

International Classes:

C07K14/78; A61K9/08; A61K38/39; A61L27/24; A61L27/60; A61L31/04; A61P17/18

Domestic Patent References:

WO2010021738A2	2010-02-25
WO2021212627A1	2021-10-28

Foreign References:

CN114369156A	2022-04-19
CN114409807A	2022-04-29
CN102906107A	2013-01-30
CN112316214A	2021-02-05

Other References:

LI YANG, ZHU CHENHUI, FAN DAIDI: "Green biological manufacture and application of recombinant collagen", CHEMICAL INDUSTRY AND ENGINEERING PROGRESS, BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY, MEMBER OF CHINESE ACADEMY OF ENGINEERING, PROFESSOR, CHINA, vol. 40, no. 3, 5 March 2021 (2021-03-05), pages 1262 - 1275, XP093080821, ISSN: 1000-6613, DOI: 10.16085/j.issn.1000-6613.2020-2109
YIN JIN, LIN JU-HWA, LI WEN-TYNG, WANG DANIEL I C, : "Evaluation of different promoters and host strains for the highlevel expression of collagen-like polymer in Escherichia coli", JOURNAL OF BIOTECHNOLOGY, vol. 100, no. 3, 13 February 2003 (2003-02-13), pages 181 - 191, XP093080824

Attorney, Agent or Firm:

BEIJING TANGSONG IP FIRM (CN)

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