Title:
INJECTION FOR INTRAVENOUS DRIP
Document Type and Number:
WIPO Patent Application WO/2007/026771
Kind Code:
A1
Abstract:
A high-content injection for intravenous drip which is prepared by adding an acidic pH regulator to an aqueous suspension containing 4-(N-(4-morpholin-4-yl)butyl)carbamoylmethyl)-5,6,7,8-tetrahydrophthalazin-1(2H)-one (Compound A) and dissolving it therein followed by, if necessary, adjusting the pH value by using a basic pH regulator. Because of being stable to light and heat, this injection is a highly useful preparation. It is preferable to adjust the pH value of the injection to 3 to 7. The concentration of the compound A is preferably from 50 mg/mL to 300 mg/mL and the viscosity of the injection is preferably from 1 mPa.s to 4 mPa.s.
Inventors:
TAKADA AKIRA (JP)
YOSHIDA MASATO (JP)
YOSHIDA MASATO (JP)
Application Number:
PCT/JP2006/317123
Publication Date:
March 08, 2007
Filing Date:
August 30, 2006
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
TAKADA AKIRA (JP)
YOSHIDA MASATO (JP)
TAKADA AKIRA (JP)
YOSHIDA MASATO (JP)
International Classes:
C07D237/32; A61K9/08; A61K31/5377; A61K47/04; A61K47/12; A61K47/16; A61P1/04; A61P3/10; A61P7/00; A61P7/02; A61P9/10; A61P11/00; A61P13/12; A61P19/00; A61P19/02; A61P21/04; A61P25/00; A61P25/04; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P43/00
Domestic Patent References:
| WO2003070707A1 | 2003-08-28 | |||
| WO2003075928A2 | 2003-09-18 |
Foreign References:
| JPH08231403A | 1996-09-10 |
Other References:
SACHIHO F.: "Chushayaku Binran-Chushayaku Haigo no Kiso-", NEN 2 GATSU 1 NICHI HAKKO, NANZANDO CO., LTD., 1977, pages 1 - 5, XP003009860
HORIOKA M. ET AL.: "Chushazai Sono Kiso to Chozai to Tekiyo", NEN 3 GATSU 22 NICHI HAKKO, NANZANDO CO., LTD., 1995, pages 21 - 22, XP003009861
YAMADA H.: "Yakuzaigaku I Chozai.Seizai", NEN 4 GATSU 15 NICHI HAKKO, KABUSHIKI KAISHA ASAKURA SHOTEN, 1995, pages 130 - 133, XP003009862
HORIOKA M. ET AL.: "Chushazai Sono Kiso to Chozai to Tekiyo", NEN 3 GATSU 22 NICHI HAKKO, NANZANDO CO., LTD., 1995, pages 21 - 22, XP003009861
YAMADA H.: "Yakuzaigaku I Chozai.Seizai", NEN 4 GATSU 15 NICHI HAKKO, KABUSHIKI KAISHA ASAKURA SHOTEN, 1995, pages 130 - 133, XP003009862
Attorney, Agent or Firm:
OHIE, Kunihisa et al. (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo 13, JP)
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