Title:
INNATE IMMUNE-ACTIVATING DRUG AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/116397
Kind Code:
A1
Abstract:
Disclosed is an innate immune-activating drug, which has broad-spectrum antiviral activity, immune adjuvant activity, promotive immunotherapy and anti-tumor activity. Specifically, disclosed are use of a compound of formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereoisomer or a mixture thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof in the preparation of an innate immune-activating drug. The compound can activate innate immunity, induce generation of I-type interferon, significantly inhibit virus infection, and promote immune function and anti-tumor.
Inventors:
HOU FAJIAN (CN)
Application Number:
PCT/CN2022/136399
Publication Date:
June 29, 2023
Filing Date:
December 02, 2022
Export Citation:
Assignee:
LUODA BIOPHARMA SUZHOU CO LTD (CN)
International Classes:
C07D219/12; A61K31/473; A61P31/12; A61P35/00
Domestic Patent References:
| WO1991002529A2 | 1991-03-07 | |||
| WO2015153535A1 | 2015-10-08 |
Foreign References:
| CN101856355A | 2010-10-13 | |||
| CN115212209A | 2022-10-21 | |||
| CN113842386A | 2021-12-28 |
Other References:
MICHELE TONELLI; GEROLAMO VETTORETTI; BRUNO TASSO; FEDERICA NOVELLI; VITO BOIDO; FABIO SPARATORE; BERNARDETTA BUSONERA; AICHA OUHT: "Acridine derivatives as anti-BVDV agents", ANTIVIRAL RESEARCH, vol. 91, no. 2, 8 May 2011 (2011-05-08), NL , pages 133 - 141, XP028236207, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2011.05.005
ISHIGAMI-YUASA MARI; WATANABE YUKO; MORI TAKAYASU; MASUNO HIROYUKI; FUJII SHINYA; KIKUCHI ERIKO; UCHIDA SHINICHI; KAGECHIKA HIROYU: "Development of WNK signaling inhibitors as a new class of antihypertensive drugs", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, no. 14, 19 May 2017 (2017-05-19), AMSTERDAM, NL, pages 3845 - 3852, XP085062457, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.05.034
MILLICH FRANK, OSTER GERALD: "Photoreduction of Acridine Dyes", J. AM. CHEM. SOC., 20 March 1959 (1959-03-20), pages 1357 - 1363, XP093074579, DOI: 10.1021/ja01515a023
GLAZ E. T., SZOLGAY ERIKA, STOGER IVANA, TALAS ' MARGARITA: "Antiviral Activity and Induction of Interferon-Like Substance by Quinacrine and Acranil", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1 May 1973 (1973-05-01), pages 537 - 541, XP055893190, DOI: 10.1128/AAC.3.5.537
ISHIGAMI-YUASA MARI; WATANABE YUKO; MORI TAKAYASU; MASUNO HIROYUKI; FUJII SHINYA; KIKUCHI ERIKO; UCHIDA SHINICHI; KAGECHIKA HIROYU: "Development of WNK signaling inhibitors as a new class of antihypertensive drugs", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, no. 14, 19 May 2017 (2017-05-19), AMSTERDAM, NL, pages 3845 - 3852, XP085062457, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.05.034
MILLICH FRANK, OSTER GERALD: "Photoreduction of Acridine Dyes", J. AM. CHEM. SOC., 20 March 1959 (1959-03-20), pages 1357 - 1363, XP093074579, DOI: 10.1021/ja01515a023
GLAZ E. T., SZOLGAY ERIKA, STOGER IVANA, TALAS ' MARGARITA: "Antiviral Activity and Induction of Interferon-Like Substance by Quinacrine and Acranil", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1 May 1973 (1973-05-01), pages 537 - 541, XP055893190, DOI: 10.1128/AAC.3.5.537
Attorney, Agent or Firm:
SHULUN & PARTNERS (SHANGHAI) (CN)
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