Title:
INSULIN HYBRID PEPTIDE COMPRISING CHYMOTRYPSIN INHIBITORY PEPTIDE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/231969
Kind Code:
A1
Abstract:
The present invention belongs to the field of protein engineering, and relates to a hybrid peptide formed by a chymotrypsin inhibitory peptide and insulin or an analogue thereof. The heterozygous insulin analogue can resist the degradation of the chymotrypsin to improve the stability, such that the curative effect of direct injection administration can be improved, and moreover, the insulin analogue can penetrate through small intestine epithelium to be directly absorbed and enter blood circulation, thereby achieving oral administration of the insulin hybrid peptide drug. The present invention further provides a method for preparing a hybrid peptide comprising the chymotrypsin inhibitory peptide and insulin or an analog thereof.
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Inventors:
WANG WEI (CN)
SHEN ZHUFANG (CN)
LIU MINZHI (CN)
ZHOU SIHAN (CN)
LI CAINA (CN)
SHEN XIN (CN)
CAO HUI (CN)
LEI LEI (CN)
YANG YAN (CN)
SHEN ZHUFANG (CN)
LIU MINZHI (CN)
ZHOU SIHAN (CN)
LI CAINA (CN)
SHEN XIN (CN)
CAO HUI (CN)
LEI LEI (CN)
YANG YAN (CN)
Application Number:
PCT/CN2023/096851
Publication Date:
December 07, 2023
Filing Date:
May 29, 2023
Export Citation:
Assignee:
INST OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCICENCES (CN)
International Classes:
A61K38/28; C07K19/00; A61P3/08; C07K1/113; C07K14/475; C07K14/81
Foreign References:
| US5049545A | 1991-09-17 | |||
| CN102439044A | 2012-05-02 | |||
| US20140377344A1 | 2014-12-25 |
Other References:
JOAKIM E. SWEDBERG ET AL.: "Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 2, 3 January 2017 (2017-01-03), pages 527 - 820, XP055933974, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01509
ANNA LEGOWSKA ET AL.: "Introduction of Non- Natural Amino Acid Residues into the Substrate- Specific P1 Position of Trypsin Inhibitor SFTI-1 Yields Potent Chymotrypsin and Cathepsin G Inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, no. 9, 27 March 2009 (2009-03-27), pages 3302 - 3307, XP026022772, ISSN: 1464-3391, DOI: 10.1016/j.bmc.2009.03.045
ANNA LEGOWSKA ET AL.: "Introduction of Non- Natural Amino Acid Residues into the Substrate- Specific P1 Position of Trypsin Inhibitor SFTI-1 Yields Potent Chymotrypsin and Cathepsin G Inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, no. 9, 27 March 2009 (2009-03-27), pages 3302 - 3307, XP026022772, ISSN: 1464-3391, DOI: 10.1016/j.bmc.2009.03.045
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