Title:
INSULIN AND IGF-1 RECEPTOR AGONISTS AND ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO2003070747
Kind Code:
A3
Abstract:
Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.
Inventors:
PILLUTLA RENUKA (US)
BRISSETTE RENEE (US)
BLUME ARTHUR J (US)
SCHAEFFER LAUGE (DK)
BRANDT JAKOB (DK)
GOLDSTEIN NEIL I (US)
SPETZLER JANE (DK)
OSTERGAARD SOREN (DK)
BRISSETTE RENEE (US)
BLUME ARTHUR J (US)
SCHAEFFER LAUGE (DK)
BRANDT JAKOB (DK)
GOLDSTEIN NEIL I (US)
SPETZLER JANE (DK)
OSTERGAARD SOREN (DK)
Application Number:
PCT/US2002/030312
Publication Date:
November 11, 2004
Filing Date:
September 24, 2002
Export Citation:
Assignee:
NOVO NORDISK AS (DK)
DGI BIOTECHNOLOGIES (US)
PILLUTLA RENUKA (US)
BRISSETTE RENEE (US)
BLUME ARTHUR J (US)
SCHAEFFER LAUGE (DK)
BRANDT JAKOB (DK)
GOLDSTEIN NEIL I (US)
SPETZLER JANE (DK)
OSTERGAARD SOREN (DK)
DGI BIOTECHNOLOGIES (US)
PILLUTLA RENUKA (US)
BRISSETTE RENEE (US)
BLUME ARTHUR J (US)
SCHAEFFER LAUGE (DK)
BRANDT JAKOB (DK)
GOLDSTEIN NEIL I (US)
SPETZLER JANE (DK)
OSTERGAARD SOREN (DK)
International Classes:
A61K38/00; A61K48/00; A61P3/10; G01N33/50; A61P43/00; C07K7/06; C07K7/08; C07K14/00; C07K14/62; C07K14/65; C12N5/07; C12N5/077; C12N5/09; C12N15/09; G01N33/15; (IPC1-7): A61K38/28; C07K7/06; C07K7/08
Domestic Patent References:
| WO1990000562A1 | 1990-01-25 |
Foreign References:
| US6028053A | 2000-02-22 |
Other References:
SCHAFFER L.: "A model for insulin binding to the insulin receptor.", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 221, 1994, pages 1127 - 1132, XP002981288
PILLUTLA R.C. ET AL: "Peptides identify the critical hotspots involved in the biological activation of the insulin receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 25, 21 June 2002 (2002-06-21), pages 22590 - 22594, XP002963018
PILLUTLA R.C. ET AL: "Peptides identify the critical hotspots involved in the biological activation of the insulin receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 25, 21 June 2002 (2002-06-21), pages 22590 - 22594, XP002963018
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