Title:
INSULIN NASAL POWDER INHALATION
Document Type and Number:
WIPO Patent Application WO/2009/094846
Kind Code:
A1
Abstract:
A insulin nasal powder inhalation and its preparing process are provided. The
powder inhalation is consist of self-emulsifying freeze-dried powder and pharmaceutically
acceptable carriers. The dry powder comprises insulin, fats(s), emulsifier(s),
antioxidant(s), supporting agent(s), bio-gel adhesive(s) and pH modifier(s),
wherein the emulsifier is a mixture of lecithin and Tween 80, and the amount of
fat in the formulation is determined by the surface area and the particle diameter
of oil droplet.
Inventors:
JIN FANG (CN)
LEI BOKAI (CN)
WEN CONG (CN)
LEI BOKAI (CN)
WEN CONG (CN)
Application Number:
PCT/CN2008/002112
Publication Date:
August 06, 2009
Filing Date:
December 29, 2008
Export Citation:
Assignee:
SHANGHAI INST PHARM INDUSTRY (CN)
JIN FANG (CN)
LEI BOKAI (CN)
WEN CONG (CN)
JIN FANG (CN)
LEI BOKAI (CN)
WEN CONG (CN)
International Classes:
A61K9/107; A61K38/28; A61K9/19; A61K47/24; A61K47/30; A61K47/44; A61P3/10
Foreign References:
| CN1919337A | 2007-02-28 | |||
| CN1919338A | 2007-02-28 | |||
| CN1456351A | 2003-11-19 | |||
| CN01801146A | 2001-04-26 | |||
| CN02804546A | 2002-07-03 | |||
| CN200480041300A | 2004-12-02 | |||
| CN200510028990A | 2005-08-22 | |||
| CN200510028991A | 2005-08-22 |
Other References:
THE PEPTIDES ANALYSIS, SYNTHESIS, BIOLOGY, vol. 4, 1981, pages 63
ZHENG SHAOHUI; DENG YIHUI: "Application of dynamic light scattering on the evaluation of the particles size and distribution of submicroemulsion for injection", CHINESE JOURNAL OF PHARMACEUTICS, vol. 3, no. 3, 2005, pages 126
See also references of EP 2243490A4
ZHENG SHAOHUI; DENG YIHUI: "Application of dynamic light scattering on the evaluation of the particles size and distribution of submicroemulsion for injection", CHINESE JOURNAL OF PHARMACEUTICS, vol. 3, no. 3, 2005, pages 126
See also references of EP 2243490A4
Attorney, Agent or Firm:
SHANGHAI CO-EFFORT IPR AGENT CO., LTD (31F Huaneng Union MansionNo. 958 Lujiazui Ring Rd, Shanghai 0, CN)
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