Title:
INTEGRATED DRUG DISCOVERY PLATFORM FOR INBORN ERROR OF METABOLISM DISORDERS
Document Type and Number:
WIPO Patent Application WO/2020/121313
Kind Code:
A8
Abstract:
The invention relates to in vivo systems and high throughput screening platform for drugs applicable in inborn error of metabolism (IEM) disorders. More specifically, the invention provides yeast screening system of candidate therapeutic compounds applicable in IEM disorders associated with accumulation of at least one metabolite. The systems of the invention comprise yeast cell/s that carry at least one manipulation in at least one yeast metabolic pathway, that leads to accumulation of said metabolite.
Inventors:
LAOR DANA (IL)
GAZIT EHUD (IL)
GAZIT EHUD (IL)
Application Number:
PCT/IL2019/051366
Publication Date:
August 13, 2020
Filing Date:
December 12, 2019
Export Citation:
Assignee:
RAMOT AT TEL-AVIV UNIV LTD (IL)
International Classes:
C12Q1/02; A61K31/122; A61P3/00
Attorney, Agent or Firm:
ZRIHAN-LICHT, Sheila et al. (IL)
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