Title:
INTEGRIN ACTIVATOR AND THERAPEUTIC AGENT FOR CHRONIC INFLAMMATORY DISEASE RELATED TO INTEGRIN ACTIVATION INHIBITION
Document Type and Number:
WIPO Patent Application WO/2023/233791
Kind Code:
A1
Abstract:
Provided are: an integrin activator that contains a substance that inhibits binding between a fibronectin and an immune inhibitory receptor LILRB4 as an active ingredient; and a therapeutic agent that contains a substance that inhibits binding between a fibronectin and an immune inhibitory receptor LILRB4 as an active ingredient and that is for a chronic inflammatory disease related to integrin activation inhibition.
Inventors:
TAKAI TOSHIYUKI (JP)
SU MEI TZU (JP)
SU MEI TZU (JP)
Application Number:
PCT/JP2023/013315
Publication Date:
December 07, 2023
Filing Date:
March 30, 2023
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
A61K45/00; A61K38/39; A61K39/395; A61P9/10; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P29/00; A61P31/00; A61P43/00
Other References:
ITOI, SO ET AL.: "3-E-WS21-12-P Immune checkpoint gp49B tethers fibronectin with integrins on macrophage cell surface", PROCEEDINGS OF THE 50TH ANNUAL MEETING OF THE JAPANESE SOCIETY FOR IMMUNOLOGY; DECEMBER 8-10, 2021, vol. 50, 1 January 2021 (2021-01-01), JP , XP009551515, ISSN: 0919-1984
TAKAI TOSHIYUKI: "Mechanism of LILRB4-mediated immune checkpoint", 2021 RESEARCH RESULTS REPORT, 1 January 2021 (2021-01-01), XP093116306
ITOI SO, TAKAHASHI NAOYUKI, SAITO HARUKA, MIYATA YUSUKE, SU MEI-TZU, KEZUKA DAI, ITAGAKI FUMIKA, ENDO SHOTA, FUJII HIROSHI, HARIGA: "Myeloid immune checkpoint ILT3/LILRB4/gp49B can co-tether fibronectin with integrin on macrophages", INTERNATIONAL IMMUNOLOGY JUN 2010, vol. 34, no. 8, 26 July 2022 (2022-07-26), pages 435 - 444, XP093116309, ISSN: 1460-2377, DOI: 10.1093/intimm/dxac023
TAKAHASHI NAOYUKI, ITOI SO, SU MEI-TZU, ENDO SHOTA, TAKAI TOSHIYUKI: "Co-localization of Fibronectin Receptors LILRB4/gp49B and Integrin on Dendritic Cell Surface", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE., TOHOKU UNIVERSITY MEDICAL PRESS, SENDAI., JP, vol. 257, no. 3, 1 January 2022 (2022-01-01), JP , pages 171 - 180, XP093116311, ISSN: 0040-8727, DOI: 10.1620/tjem.2022.J014
TAKAI TOSHIYUKI: "Mechanism of LILRB4-mediated immune checkpoint", 2021 RESEARCH RESULTS REPORT, 1 January 2021 (2021-01-01), XP093116306
ITOI SO, TAKAHASHI NAOYUKI, SAITO HARUKA, MIYATA YUSUKE, SU MEI-TZU, KEZUKA DAI, ITAGAKI FUMIKA, ENDO SHOTA, FUJII HIROSHI, HARIGA: "Myeloid immune checkpoint ILT3/LILRB4/gp49B can co-tether fibronectin with integrin on macrophages", INTERNATIONAL IMMUNOLOGY JUN 2010, vol. 34, no. 8, 26 July 2022 (2022-07-26), pages 435 - 444, XP093116309, ISSN: 1460-2377, DOI: 10.1093/intimm/dxac023
TAKAHASHI NAOYUKI, ITOI SO, SU MEI-TZU, ENDO SHOTA, TAKAI TOSHIYUKI: "Co-localization of Fibronectin Receptors LILRB4/gp49B and Integrin on Dendritic Cell Surface", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE., TOHOKU UNIVERSITY MEDICAL PRESS, SENDAI., JP, vol. 257, no. 3, 1 January 2022 (2022-01-01), JP , pages 171 - 180, XP093116311, ISSN: 0040-8727, DOI: 10.1620/tjem.2022.J014
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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