Title:
INTERFERING RNA FOR INHIBITING EXPRESSION OF MELANOPHILIN (MLPH) GENE, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/078534
Kind Code:
A1
Abstract:
An interfering RNA for inhibiting MLPH expression, which comprises: any one or more nucleotide sequences as shown in SEQ ID NOs: 1-20 or SEQ ID NOs: 27-38. The siRNA has good activity in inhibiting MLPH mRNA expression, with an inhibition rate reaching 70-80%. A chemically modified interfering RNA sequence has better activity in inhibiting MLPH mRNA expression. Further provided is a lipid nano-delivery system, where the siRNA is delivered to a suitable subcutaneous location and performs its biological effects, with broad applications in whitening products. Additionally provided is a medication comprising an interfering RNA antibody/nucleic acid conjugate, used for preventing and/or treating hyperpigmentation or diseases related to an increase in MLPH expression.
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Inventors:
JIA HONGLI (CN)
LIN MEINA (CN)
YANG MAI (CN)
CHEN XIAOMENG (CN)
GUO JUN (CN)
WANG QINGBIN (CN)
ZHAO XUAN (CN)
LIN MEINA (CN)
YANG MAI (CN)
CHEN XIAOMENG (CN)
GUO JUN (CN)
WANG QINGBIN (CN)
ZHAO XUAN (CN)
Application Number:
PCT/CN2023/124033
Publication Date:
April 18, 2024
Filing Date:
October 11, 2023
Export Citation:
Assignee:
JENKEM TECH CO LTD BEIJING (CN)
International Classes:
C07K14/00; A61K38/00; A61K38/16; A61P17/00
Domestic Patent References:
| WO2010149785A1 | 2010-12-29 |
Foreign References:
| CN114502571A | 2022-05-13 | |||
| US20220169678A1 | 2022-06-02 | |||
| US20220183949A1 | 2022-06-16 | |||
| CN114149337A | 2022-03-08 | |||
| CN114276535A | 2022-04-05 |
Other References:
MYUNG, C.H. ET AL.: "Regulation of Melanophilin (Mlph) Gene Expression by the Glucocorticoid Receptor (GR)", SCIENTIFIC REPORTS, vol. 11, 19 August 2021 (2021-08-19), XP093129025, DOI: 10.1038/s41598-021-96276-w
LEE JEONG AH, HWANG SEOK JOON, HONG SUNG CHAN, MYUNG CHEOL HWAN, LEE JI EUN, PARK JONG IL, HWANG JAE SUNG: "Identification of MicroRNA Targeting Mlph and Affecting Melanosome Transport", BIOMOLECULES, vol. 9, no. 7, 8 July 2019 (2019-07-08), pages 265, XP093050174, DOI: 10.3390/biom9070265
LEE JEONG AH, HWANG SEOK JOON, HONG SUNG CHAN, MYUNG CHEOL HWAN, LEE JI EUN, PARK JONG IL, HWANG JAE SUNG: "Identification of MicroRNA Targeting Mlph and Affecting Melanosome Transport", BIOMOLECULES, vol. 9, no. 7, 8 July 2019 (2019-07-08), pages 265, XP093050174, DOI: 10.3390/biom9070265
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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