Title:
INTERFERON ALPHA MUTANT AND ITS POLYETHYLENE GLYCOL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2008/074230
Kind Code:
A1
Abstract:
IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in
existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral
activity and prolonged in vivo half-life are also provided, wherein a polyethylene
glycol moiety is covalently bound to the free Cys residue of a IFN-alpha mutant.
The preparation methods of PEG derivatives of IFN-alpha mutants and medical
compositions comprising the derivatives are also provided.
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Inventors:
LIU JINYI (CN)
NIU XIAOXIA (CN)
ZHOU MINYI (CN)
YANG YI (CN)
SUN JIANBO (CN)
CHENG YONGQING (CN)
NIU XIAOXIA (CN)
ZHOU MINYI (CN)
YANG YI (CN)
SUN JIANBO (CN)
CHENG YONGQING (CN)
Application Number:
PCT/CN2007/003711
Publication Date:
June 26, 2008
Filing Date:
December 21, 2007
Export Citation:
Assignee:
BEIJING TRI PRIME GENETIC ENGI (CN)
BEIJING BIO TECH DEV CO LTD (CN)
LIU JINYI (CN)
NIU XIAOXIA (CN)
ZHOU MINYI (CN)
YANG YI (CN)
SUN JIANBO (CN)
CHENG YONGQING (CN)
BEIJING BIO TECH DEV CO LTD (CN)
LIU JINYI (CN)
NIU XIAOXIA (CN)
ZHOU MINYI (CN)
YANG YI (CN)
SUN JIANBO (CN)
CHENG YONGQING (CN)
International Classes:
C07K14/56; A61K38/21; A61K47/48; A61P31/12; A61P35/00; A61P37/02; C07K17/08; C12N15/21
Foreign References:
| CN1754889A | 2006-04-05 | |||
| CN1738640A | 2006-02-22 | |||
| KR20020067105A | 2002-08-22 | |||
| CN1511849A | 2004-07-14 | |||
| CN1355842A | 2002-06-26 |
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (Fortune International CenterNo. 17 Daliushu Road, Beijing 1, CN)
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