Title:
INTERFERON VAGINAL EFFERVESCENT CAPSULES AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/084612
Kind Code:
A1
Abstract:
Interferon vaginal effervescent capsules and a preparation method therefor. The interferon vaginal effervescent capsules consist of interferon freeze-dried powder, effervescent powder, and pharmaceutically acceptable accessories, the mass ratio of the interferon freeze-dried powder to the effervescent powder being 1:1.0~1.5, and preferably, 1:1.2. The vaginal effervescent capsules continuously release interferon for a long time at a low dosage, vaginal continuous low-dosage drug administration can be realized, local symptoms can be better removed, the treatment time can be effectively prolonged, and adverse effects of long-term medication are reduced; and meanwhile, during a continuous six-month acceleration test under the temperature of 40°C±2°C and a two-year long-term test under the temperature of 25°C±2°C of the vaginal effervescent capsules, both the valence (bioactivity) and the appearance thereof are not obviously changed, and good stability is expressed.
Inventors:
LIU HUI (CN)
ZHONG JINGYU (CN)
LI GUANYING (CN)
WANG JIAN (CN)
WANG YANG (CN)
ZHONG JINGYU (CN)
LI GUANYING (CN)
WANG JIAN (CN)
WANG YANG (CN)
Application Number:
PCT/CN2016/106370
Publication Date:
May 26, 2017
Filing Date:
November 18, 2016
Export Citation:
Assignee:
SHANGHAI HUAXIN HIGH BIOTECHNOLOGY INC (CN)
International Classes:
A61K9/48; A61K38/21; A61K47/26; A61K47/38; A61P15/00
Foreign References:
| CN1569224A | 2005-01-26 | |||
| CN105326807A | 2016-02-17 | |||
| CN101088558A | 2007-12-19 | |||
| CN101642564A | 2010-02-10 | |||
| CN1970079A | 2007-05-30 | |||
| US6372218B1 | 2002-04-16 |
Other References:
WANG: "Study on the preparation of effervescent tablets of Recombinant Human Interferon α-2b", JOURNAL OF JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE, vol. 17, no. 4, 31 August 2005 (2005-08-31), pages 51 - 52
Attorney, Agent or Firm:
BEIJING YUANZHONG INTELLECTUAL PROPERTY AGENT LTD. (CN)
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