Title:
INTERLEUKIN-6 POLYETHYLENE GLYCOL CONJUGATE AND ITS PREPARING METHOD AND USE
Document Type and Number:
WIPO Patent Application WO/2006/116948
Kind Code:
A1
Abstract:
A interleukin-6 polyethylene glycol conjugate and its preparing method and medical compositions comprising the conjugate and pharmaceutically acceptable excipients. The conjugate according to the invention is used for producing medicines treating thrombocytopenia, chemotherapy adjuvants or medicines enhancing immunity. The mono-PEG-modified IL-6 enhances markedly biostability, has longer in vivo half life and lower plasma clearance compared with unmodified IL-6, resulting in a great decrease in frequency and dose of administration as well as side effects. The mono-PEG-modified IL-6 according to the present invention can reach medicinal standards due to its good uniformity.
Inventors:
ZHANG XUEMEI (CN)
YUAN TAO (CN)
ZHANG KE (CN)
RAO HAILIN (CN)
DENG JIE (CN)
WANG ZHIJIE (CN)
YUAN TAO (CN)
ZHANG KE (CN)
RAO HAILIN (CN)
DENG JIE (CN)
WANG ZHIJIE (CN)
Application Number:
PCT/CN2006/000891
Publication Date:
November 09, 2006
Filing Date:
April 30, 2006
Export Citation:
Assignee:
CHENGDU INST OF BIOLOG PRODUCT (CN)
ZHANG XUEMEI (CN)
YUAN TAO (CN)
ZHANG KE (CN)
RAO HAILIN (CN)
DENG JIE (CN)
WANG ZHIJIE (CN)
ZHANG XUEMEI (CN)
YUAN TAO (CN)
ZHANG KE (CN)
RAO HAILIN (CN)
DENG JIE (CN)
WANG ZHIJIE (CN)
International Classes:
C07K14/54; A61K38/20; A61K47/48; A61P7/00; A61P37/02; C07K1/14; C07K14/565; C07K17/08
Domestic Patent References:
| WO2002026265A2 | 2002-04-04 | |||
| WO2005019260A1 | 2005-03-03 |
Foreign References:
| US5264209A | 1993-11-23 | |||
| KR20030045414A | 2003-06-11 |
Other References:
ROBERTS M.J. ET AL.: "Chemistry for peptide and protein PEGylation", ADVANCED DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 459 - 476, XP002349367
TSUTSUMI ET AL.: "Polyethylene glycol modification of interleukin-6 enhances its thrombopoietic activity", JOURNAL OF CONTROLLED RELEASE, vol. 33, 1995, pages 447 - 451, XP000498932
XU J. ET AL.: "Preliminary study on chemical modification of interferon-beta by polyethylene glycol", PROGRESS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 32, no. 3, 2004, pages 30 - 33
TSUTSUMI ET AL.: "Polyethylene glycol modification of interleukin-6 enhances its thrombopoietic activity", JOURNAL OF CONTROLLED RELEASE, vol. 33, 1995, pages 447 - 451, XP000498932
XU J. ET AL.: "Preliminary study on chemical modification of interferon-beta by polyethylene glycol", PROGRESS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 32, no. 3, 2004, pages 30 - 33
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (Tower B INDO Mansion, No. 48-JIA Zhichun Roa, Haidian District Beijing 8, CN)
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