Title:
INTERMEDIATE OF POLYAMINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/078277
Kind Code:
A1
Abstract:
An intermediate of a polyamine derivative, a preparation method therefor, and a use thereof. The intermediate is easy to prepare and high in purity; and when the intermediate is used for preparing the polyamine derivative, the obtained product is high in purity, the operation is simple and convenient, the purity and yield of the polyamine derivative are improved, the purification operation for the product is simplified, and the industrial production of the polyamine derivative and a medicinal salt thereof can be improved. Further provided is a preparation method for the polyamine derivative, the operation thereof is simple and convenient, and the purity of the obtained product is high. The method has a very good application prospect in the field of chemical medicines.
Inventors:
XIA YISHUN (CN)
RAO XIANG (CN)
CAI CHAO (CN)
LIU XINRONG (CN)
LI LEI (CN)
LI ZHENWU (CN)
YANG BO (CN)
RAO XIANG (CN)
CAI CHAO (CN)
LIU XINRONG (CN)
LI LEI (CN)
LI ZHENWU (CN)
YANG BO (CN)
Application Number:
PCT/CN2022/129147
Publication Date:
May 11, 2023
Filing Date:
November 02, 2022
Export Citation:
Assignee:
WUHAN WUYAO SCI&TECH CO LTD (CN)
International Classes:
C07C233/40; A61K31/165; A61K31/166; A61P29/00; A61P37/00; C07C231/12; C07C235/34; C07D207/404
Foreign References:
| US5348955A | 1994-09-20 | |||
| US5292726A | 1994-03-08 | |||
| CN105348137A | 2016-02-24 | |||
| CN102267922A | 2011-12-07 | |||
| CN111961204A | 2020-11-20 |
Other References:
MANGUM, C. L. ET AL.: "The Total Syntheses of JBIR-94 and Two Synthetic Analogs and Their Cytotoxicities Against A549 (CCL-185) Human Small Lung Cancer cells", TETRAHEDRON LETTERS, vol. 61, 4 November 2019 (2019-11-04), XP085967886, DOI: 10.1016/j.tetlet.2019.151360
DATABASE Registry CAS; 16 November 1984 (1984-11-16), XP093078329, Database accession no. 154315-80-7
DATABASE Registry CAS; 16 November 1984 (1984-11-16), XP093078329, Database accession no. 154315-80-7
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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