Title:
INTERMEDIATE AND USE AND METHOD OF INTERMEDIATE IN PREPARATION OF PYRROLOQUINOLINE QUINONE
Document Type and Number:
WIPO Patent Application WO/2024/098531
Kind Code:
A1
Abstract:
An intermediate and a use and method of the intermediate in preparation of pyrroloquinoline quinone. The intermediate compound has a structure as shown in formula I or formula II. In the structure, R1 is C1-C3 straight-chain or branched-chain alkyl; R2 is nitro or amino; R3 is hydrogen or an amino protecting group; R4 is selected from hydrogen and C1-C3 straight-chain or branched-chain alkyl. The method has a simple route, mild reaction conditions and high yield, avoids the use of an oxidizing agent, ceric ammonium nitrate, and achieves the industrial large-scale production of pyrroloquinoline quinone.
Inventors:
CAI CHENGFA (CN)
WANG JINGLIN (CN)
MU ZHENQIANG (CN)
LIU GUIZHEN (CN)
YU RUIMEI (CN)
LIAN QIONGQIONG (CN)
TIAN CUICUI (CN)
WANG JINGLIN (CN)
MU ZHENQIANG (CN)
LIU GUIZHEN (CN)
YU RUIMEI (CN)
LIAN QIONGQIONG (CN)
TIAN CUICUI (CN)
Application Number:
PCT/CN2022/142380
Publication Date:
May 16, 2024
Filing Date:
December 27, 2022
Export Citation:
Assignee:
SHANDONG YUANLITAI MEDICAL TECH CO LTD (CN)
International Classes:
C07D215/50; C07C231/02; C07C233/25; C07C233/43; C07D471/04
Foreign References:
| CN107089982A | 2017-08-25 | |||
| CN110981873A | 2020-04-10 | |||
| CN111087395A | 2020-05-01 | |||
| CN101193888A | 2008-06-04 |
Other References:
SLEATH, P. R. ET AL.: "Synthesis of 7,9-didecarboxymethoxatin (4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2-carboxylic acid) and comparison of its chemical properties with those of methoxatin and analogous o-quinones. Model studies directed toward the action of PQQ requiring bacterial oxidoreductases and mammalian p", J. AM. CHEM. SOC., vol. 107, no. 11, 31 December 1985 (1985-12-31), pages 3328 - 3338, XP002483159, DOI: 10.1021/ja00297a044
Attorney, Agent or Firm:
JINAN SHENGDA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
Download PDF:
Previous Patent: INTERMEDIATE AND METHOD FOR PREPARING PYRROLOQUINOLINE QUINONE
Next Patent: TRACTION TRANSFORMER
Next Patent: TRACTION TRANSFORMER