INTERMEDIATES AND PROCESS OF COMPOUNDS FOR THE DEGRADATION OF EGFR KINASE

Title:

INTERMEDIATES AND PROCESS OF COMPOUNDS FOR THE DEGRADATION OF EGFR KINASE

Document Type and Number:

WIPO Patent Application WO/2024/099400

Kind Code:

A1

Abstract:

Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

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Inventors:

LEI BAILIN (CN)
LIU HUAQING (CN)
ZHAO YIZHOU (CN)
HAN SONGZHE (CN)
LIAO SHAOHAN (CN)
TANG JIA (CN)
WANG ZHIWEI (CN)

Application Number:

PCT/CN2023/130819

Publication Date:

May 16, 2024

Filing Date:

November 09, 2023

Export Citation:

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Assignee:

BEIGENE BEIJING CO LTD (CN)

International Classes:

C07D498/22

Domestic Patent References:

WO2023001069A1	2023-01-26
WO2021121261A1	2021-06-24

Foreign References:

CN113527335A	2021-10-22
CN114656482A	2022-06-24
CN114163454A	2022-03-11
CN114007698A	2022-02-01

Attorney, Agent or Firm:

KING & WOOD MALLESONS (CN)

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