INTERMEDIATES FOR VITAMIN D AND PROCESSES FOR THE PREPARATION THEREOF

Title:

INTERMEDIATES FOR VITAMIN D AND PROCESSES FOR THE PREPARATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2001/074764

Kind Code:

A1

Abstract:

Intermediates for the synthesis of 1$g(a)-hydroxyvitamin D derivatives useful as drugs; and processes for the preparation of the same. Specifically, a process for the preparation of a compound of the general formula (5), which comprises reacting compound (1) with a compound of the general formula (4) in the presence of a palladium catalyst to obtain a compound of the general formula (2), converting this compound (2) into a compound of the general formula (3) through the catalytic reduction of the compound (2) in the presence of a Lindlar catalyst and hydrogen gas and the heating of the obtained product, and oxidizing the compound (3) with an oxidizing agent; and compounds represented by the general formulae (1) to (3).

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Inventors:

KOGA MASAHIRO (JP)
MINOSHIMA TORU (JP)

Application Number:

PCT/JP2000/002033

Publication Date:

October 11, 2001

Filing Date:

March 30, 2000

Export Citation:

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Assignee:

TEIJIN LTD (JP)
KOGA MASAHIRO (JP)
MINOSHIMA TORU (JP)

International Classes:

C07C309/65; C07C401/00; C07F7/18; (IPC1-7): C07C317/20; C07C401/00; B01J31/24; B01J31/30

Domestic Patent References:

WO1997037972A1

1997-10-16

Foreign References:

JPH023695A

1990-01-09

Other References: