INTERNAL IMAGE ANTIBODIES FOR OPTICAL IMAGING AND THERAPY

Title:

INTERNAL IMAGE ANTIBODIES FOR OPTICAL IMAGING AND THERAPY

Document Type and Number:

WIPO Patent Application WO2003011106

Kind Code:

A3

Abstract:

Compositions and methods using internal image antibodies for phot diagnasis and/or phototherapy. The internal image antibodies are conjugated with a photoactive molecule such as a dye or photosensitizer, to target specific regions, such as biological receptors the photoactive molecules are then activated for diagnosis or therapy. Advantageously, the internal image antibody is specific for a biological receptor, but does not require isolation of the receptor to prepare the antibody, and provides the desired specific ty and selectivity for targeted diagnosis for therapy.

Inventors:

RAJAGOPALAN RAGHAVAN (US)
BUGAJ JOSEPH E (US)
ACHILEFU SAMUEL I (US)
DORSHOW RICHARD B (US)

Application Number:

PCT/US2002/022755

Publication Date:

December 02, 2004

Filing Date:

July 18, 2002

Export Citation:

Click for automatic bibliography generation Help

Assignee:

MALLINCKRODT INC (US)
RAJAGOPALAN RAGHAVAN (US)
BUGAJ JOSEPH E (US)
ACHILEFU SAMUEL I (US)
DORSHOW RICHARD B (US)

International Classes:

A61K41/00; A61K49/00; A61P7/02; A61K39/395; A61P9/10; A61P35/00; A61P43/00; C07K16/28; C07K16/42; C12P21/08; (IPC1-7): A61K35/04; C07K16/00; C12P21/08

Foreign References:

US5667764A	1997-09-16
US4818684A	1989-04-04
US6485704B1	2002-11-26

Other References: