Title:
INTESTINE-SPECIFIC PARTIAL AGONISTS OF FARNESOID X RECEPTOR AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/005520
Kind Code:
A1
Abstract:
The present invention relates to intestine-specific partial agonists of farnesoid X receptor (FXR), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with FXR activity.
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Inventors:
KIM DAE-KEE (KR)
SHIM SOYEON (KR)
SHIM SOYEON (KR)
Application Number:
PCT/KR2023/008982
Publication Date:
January 04, 2024
Filing Date:
June 28, 2023
Export Citation:
Assignee:
EWHA DRUGDESIGNHOUSE CO LTD (KR)
International Classes:
C07C255/60; A61K31/216; A61K31/277; A61K31/357
Domestic Patent References:
| WO2020198537A1 | 2020-10-01 | |||
| WO2004046068A2 | 2004-06-03 |
Foreign References:
| US20180244606A1 | 2018-08-30 | |||
| US20170066724A1 | 2017-03-09 |
Other References:
SHIM SOYEON, KRISHNAIAH MADDEBOINA, SANKHAM MADHUSUDANA REDDY, KIM INHA, LEE YOSEOB, SHIN IRIN, OH A REUM, LEE HWA JEONG, VU THI N: "Discovery of ( E )-3-(3-((2-Cyano-4′-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 14, 28 July 2022 (2022-07-28), US , pages 9974 - 10000, XP093122117, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.2c00641
Attorney, Agent or Firm:
HALLA PATENT & LAW FIRM (KR)
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